动态监测乙型肝炎病毒大蛋白在乙肝治疗中的作用

Effect of dynamic monitoring of the large envelope protein of hepatitis B virus in the therapy of viral hepatitis B

目的观察乙型肝炎病毒大蛋白(HBV-LP)在乙肝治疗中的动态变化,为临床应用提供依据。方法收集衡阳市中心医院自2008年1月至2010年6月间收治的乙肝患者共160例。分别在抗病毒治疗0,3,6,9,12个月时进行血清HBV DNA和HBV-LP检测。结果乙肝患者中HBV-LP与HBV DNA的阳性率及治疗后HBV-LP与HBV DNA的转阴率无显著差异,但HBV DNA的平均转阴时间短于HBV-LP。治疗有效的患者在治疗过程中HBV-LP与HBV DNA均下降,但HBV DNA下降的幅度要快于HBV-LP下降的幅度;而治疗无效的患者在治疗过程中HBV-LP与HBV DNA表达无显著变化。结论动态监测乙型肝炎病毒大蛋白可作为病毒复制和疗效判定的重要指标。

Objective To observe the effect of dynamic monitoring of the large envelope protein of hepatitis B virus in the therapy of viral hepatitis B.Methods 160 patients with viral hepatitis type B from 2008 Jan to 2010 June in our hospital were collected.The level of HBV DNA and HBV-LP were detected at 0,3,6,9 and 12 month after antiviral therapy.Results The positive rate and the negative conversion rate of HBV DNA and HBV-LP had no significant difference in patients with viral hepatitis B.However,the time of the average negative conversion rate of HBV DNA was significantly shorter than that of HBV-LP.The level of HBV DNA and HBV-LP decreased significantly during the process of treatment in the patients who accepted effective treatment.However,it declined more quickly in HBV DNA than that in HBV-LP.While no significant difference occurred during the process of treatment in the patients who accepted ineffective treatment.Conclusion Dynamic monitoring of the large envelope protein of hepatitis B virus could be an important indicator in viral replication and the judgment of curative effect.