联苯苄唑乳膏联合中药复方透骨草溶液治疗角化过度型足癣临床疗效观察

Treatment effect of Bifonazole Cream and Traditional Medicine Solution Compound in Treating Keratotic Tinea Pedis.

目的:观察联苯苄唑乳膏外用联合中药复方透骨草溻渍治疗角化过度型足癣的临床疗效。方法:采用随机对照法观察联苯苄唑乳膏联合中药溻渍(联合组)及单用联苯苄唑乳膏(联苯苄唑组)或中药溻渍(中药组)治疗角化过度型足癣的临床疗效。结果:用药后2周联合组、联苯苄唑组、中药组的显效率分别为70%、60%、30%,有效率分别为76.7%、60%、30%,联合组、联苯苄唑组的显效率、有效率均明显高于中药组,P<0.05;联合组的显效率、有效率略高于联苯苄唑组,但两者相比无明显统计学差异,P>0.05。真菌学评价:用药后2周联合组真菌清除率73%,联苯苄唑组57%,中药组50%。联合组真菌清除率显著高于联苯苄唑组、中药组,P<0.05。联苯苄唑组真菌清除率略高于中药组,但两者相比无明显统计学差异,P>0.05。除中药组2例患者出现接触性皮炎外,其余患者均未见显著不良反应。结论:中西医结合治疗角化过度型足癣的临床效果好,且无明显不良反应,使用方便,具有极好的性价比,值得临床推广使用。

Objective ：To observe the clinical efficiency of bifonazole cream and traditional medicine solution compound in treating keratotic tinea pedis.Methods ：A randomized controlled clinical trial was conducted to compare combination group and Bifonazole group and traditional group in Treating Keratotic Tinea Pedis.Results ：The obviously efficiency ratios and effective ratios of combination group and bifonazole group were obviously prior to traditional group in two weeks after stopping treatment（P0.05）.There were no statistically significant difference between combination group and bifonazole group of the obviously efficiency ration and effective ratios（P0.05）.The mycological effects of combination group was obviously prior to bifonazole group and traditional group in two weeks after stopping treatmen（tP0.05）.There were no statistically significant difference between traditional group and bifonazole group of the mycological effects（P0.05）.In this trial there was no obviously side-effect in all groups except for two case of contact dermatitis.Conclusion ：The combination group has good clinical efficiency in treating keratotic tinea pedis and the safety of combinational therapy was well evaluated,so we advise it could be used in clinical widely.