血清降钙素原检测对儿童下呼吸道感染的诊断价值

Diagnositic value of serum procalcitonin in lower respiratory tract infection in children

目的探讨血清降钙素原（PCT）检测对儿童下呼吸道感染的诊断价值。方法应用免疫荧光法定量法检测60例呼吸系统感染患儿PCT，同时与患儿的白细胞计数（WBC）、C反应蛋白（CRP）进行比较。结果细菌感染组PCT阳性率显著高于非细菌感染组（P〈0．01）。细菌感染组中PCT阳性率与CRP阳性率差异无统计学意义（P〉0．05），而高于WBC阳性率（P〈0．05）；非细菌感染组中PCT阳性率明显低于CRP和WBC阳性率（均P〈0．01）。结论在儿童下呼吸道细菌感染疾病中，PCT对细菌感染的诊断价值优于WBC及CRP等传统炎症指标。

Objective To investigate the diagnostic value of serum procalationin（PCT） in children with lower respiratory tract infection. Methods The serum PCT level in 60 children with lower respiratory tract infection was measured by electrochemiluminescence immune assay（ECLIA）. The results were compared with the levels of C-reaction protein（CRP） and white blood cell count （WBC）. Results The positive rate of the serum PCT in bacterial infected group was significantly higher than in non-bacterial infected group（ P 〈 0.01 ）. In bacterial infected group, both positive rate of the serum PCT and CRP had no statistically significant difference（ P 〉0.05 ） ,whereas ,positive rate of the serum PCT was significantly higher than that of WBC （ P 〈 0.05 ） ; In non-bacterial infected group, positive rate of the serum PCT was significantly lower than that of CRP and WBC （ all P 〈 0.01 ）. Conclusion In children with lower respiratory tract infection, PCT was significantly better and specific for bacterial infection, diagnosis than CRP or WBC count.