COX-2、VEGF-C在头颈鳞癌中的表达及意义

COX-2、VEGF-C expression and its clinical significance in HNSCC

目的:探讨环氧化酶2(cyclooxygenase-2,COX-2)和血管内皮生长因子C(vascular endo-thelial growth factor-C,VEGF-C)在头颈鳞癌(head neck squamous cell carcinoma,HNSCC)中的表达及意义。方法:用免疫组化S-P法检测104例HNSCC组织中COX-2、VEGF-C蛋白的表达情况,分析其临床病理意义。结果:104例HNSCC组织中COX-2、VEGF-C的阳性表达率分别为69.23%、74.04%,显著高于正常头颈部粘膜组织(P<0.05)。HNSCC组织中颈淋巴结转移者的COX-2、VEGF-C表达均高于无颈部淋巴结转移者(P<0.05),且COX-2和VEGF-C的表达呈正相关(r=0.366,P<0.05)。结论:HNSCC中COX-2、VEGF-C的阳性表达明显增高并与颈部淋巴结转移密切相关。在HNSCC的侵袭、转移过程中,COX-2和VEGF-C的表达可能具有协同作用,可望用于对HNSCC颈淋巴结侵袭、转移潜能的评估。

Objective：To explore the significance of COX-2 and VEGF-C expression in head neck squamous cell carcino- ma （HNSCC）. Methods：Immunohistochemical method was used to assess the expression of COX-2 and VEGF-C in 104 cases of HNSCC. The clinical pathological significance of COX-2 and VEGF-C expression were evaluated. Results：The positive rates of COX-2 and VEGF-C in HNSCC tissues （69.23% and 74.04%, respectively） were significantly higher than those in the normal oral mucousa （ P 〈 0.05 ）. The expressions of COX-2 and VEGF-C were remarkably higher in lymph node metastasis positive patients than those in metastasis negative patients（ P 〈 0.05 ）. Positive correlation was ob- served between the expression of COX-2 and VEGF-C proteins （r = 0. 366,P = 0.000）. Conclusion ： COX-2 and VEGF-C were overexpressed and were closely correlated with regional lymph node metastasis in HNSCC. The positive correlation between the two proteins showed that they cooperatively participated in the invasion and metastasis of HNSCC.