不同砷剂治疗急性早幼粒细胞白血病临床分析

Clinical analysis of Different Arsenic Trioxide Treatment of Acute Promyelocytic Leukemia

目的:比较三氧化二砷(AS2O3)和复方柏子仁(AS4S4)治疗急性早幼粒细胞白血病(APL)的疗效与不良反应。方法:维甲酸(ATRA)联合AS2O3(Ⅰ组)或AS4S4(Ⅱ组)诱导缓解治疗APL,统计分析两组CR率及不良反应。结果:Ⅰ组和Ⅱ组的CR率分别为96%、100%,两组疗效及不良反应均无显著差异(P>0.05)。结论:AS2O3和AS4S4治疗APL疗效均显著,不良反应能耐受。

Objective：To asses the effect and toxic side effects of arsenic trisulfide（AS2O3） and tetra-arsenic tetra-sulfide（AS4S4）in the treatment of acute promyelocytic leukemia（APL）.Methods：The patients of APL were treated with All-trans retinoic acid（ATRA） combined with AS2O3（Ⅰ group） or AS4S4（Ⅱ group） as induction therapy,the CR rate and toxic side effect were analyzed between the two groups.Result：The CR rate ofⅠgroup and Ⅱgroup were 96%、100%,with no statistical difference in effect and toxic side effect（P〉0.05）.Conclusion：AS2O3 and AS4S4 are effective for APL with mild toxic side effects.