降纤酶治疗急性脑梗死的临床观察

Clinical Outcome of Defibrase in the Treatment Acute Cerebral Infarction

目的 探讨降纤酶治疗急性脑梗死的临床疗效。 方法 符合入选条件发病 6～ 2 4 h的急性脑梗死患者 1 2 0例 ,随机分为治疗组与对照组。治疗组 60例在应用同等药物治疗的同时 ,加用降纤酶首次 1 0 u静脉滴注 ,其后每日 5u维持治疗 5天。治疗前后测定纤维蛋白原、凝血酶原时间 ,评定神经功能恢复情况。 结果 治疗组有效率 87% ,对照组有效率 62 %。

Objective To evalute the outcome of defibrase in the treatment of acute cerebral infarction Methods 120 patients with acute cerebral infarction within 6~24 hours onset wefre randomly allocated to defibrase and control groupsDefibrase groups receive initial intravenous in fusion of defibrase 10u in 250ml nomal saline over 1 hours whithin 6~24 hours of strokeSubsqent infusion of defibrase 5u for five daysThe pionts before and after treament included clinical neurological defcts scale of stroke and the level of plasma fibrinogen Result Defibrase groups improvement 87%,control groups improvenment 62% Conclutions This study showed that defibrase appears safe and effective for acute cerebral infarction