入院时血浆脑利钠肽水平与急性缺血性脑卒中脑梗死体积的关系

The relationship between plasma brain natriuretic peptide level on admission and infarction volume in patients with Acute Ischemic Stroke

目的探讨急性缺血性脑卒中患者入院时血浆脑利钠肽（BNP）水平能否成为急性缺血性脑卒中患者脑梗死体积大小的预测指标。方法选择发病24小时内的急性缺血性脑卒中患者88例，于入院24小时内检测血浆BNP，并将其分为大而积梗死组（19例）与非大面积梗死组（69例）。结果脑梗死体积与入院时BNP值等级有显著相关性（P〈0．01），大面积梗死组患者血浆BNP水平显著高于非大面积梗死组[（843．32±420．95）pg／ml和（328．72±328．08）pg／ml，P〈0．01]。入院时血浆BNP水平≥603．50pg／ml可作为大面积脑梗死的预测指标，其敏感性为96．00％，特异性为76．19％。结论入院时血浆BNP水平可作为急性缺血性脑卒中患者脑梗死体积的预测因子之一。

Objective To estimate the predictor application of the plasma brain natriuretic pep- tide（BNP） level in acute ischenfic stroke patients by investigating the relationship between the plasma BNP level and infarction volume. Methods 88 patients with acute ischemic stroke were prospectively en- rolled within 24 hours of onset, and the plasma brain natriuretic peptide were measured and compared be- tween the large area infarction group （n = 19） and the non-large area infarction group （n = 69）. Results There was a significant correlation between infarction volume and the plasma BNP level in patients with acute ischemic stroke（ P 〈 0.01 ）. The plasma BNP levels on admission were significantly higher in the large group than in the non-large group[ （843.32 ±420.95 ） pg/ml vs （ 328.72 ± 328.08 ） pg/ml, P 〈 0.01 ]. BNP≥603.50 pg/ml can be the predictor index for large area infarction,and its sensitivity and specificity were 96.00% and 76.19% ,respectively. Conelusion BNP on admission can predict infarction volume in patients with acute isehemic stroke.