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CD4^+CD25^+调节性T细胞与妊娠期高血压病子痫前期发生关系的探讨 被引量：1

Relationship Between CD4^+CD25^+ T Lymphocytes and Preeclampsia of Hypertensive Disorders in Pregnancy
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摘要 目的:观察具有免疫抑制作用的CD4+CD25+T细胞的数量以及相关因素雌激素与妊娠期高血压病子痫前期发生的关系。方法:流式细胞技术分析,测定CD4+CD25+T细胞的数量,放射免疫测定血清雌激素。结果:妊娠期高血压病子痫前期患者,其CD4+CD25+T细胞的数量减少,且血雌三醇水平有不同程度的降低。结论:①CD4+CD25+T细胞数量的改变在妊娠期高血压病的发病机制中起重要的作用。②雌激素能帮助维持免疫耐受。 Objective To study the relationship between the numbers of immunosuppression CD4＋CD25＋ T lymphocytes,estrogen level and preeclampsia of hypertensive disorders in pregnancy.Methods Numbers of CD4＋CD25＋ T lymphocytes were measured by flow cytometry.Estrogen level of blood serum were measured by radioimmunoassay.Results Numbers of CD4＋CD25＋ T lymphocytes were reduced,and the estriol level of blood serum were decreased in different degree in preeclampsia of hypertensive disorders in pregnancy.Conclusion Changes of the numbers of CD4＋CD25＋ T lymphocytes act an important role in the pathogenesis of hypertensive disorders in pregnancy;Estrogen could help to maintain the immune tolerance.
作者 李佳倪 赵卫华 张琼丽
机构地区 深圳市第二人民医院妇产科
出处 《深圳中西医结合杂志》 2012年第4期236-238,共3页 Shenzhen Journal of Integrated Traditional Chinese and Western Medicine
基金 深圳市科技计划项目(201102053)
关键词 CD4+CD25+T细胞 子痫前期 雌三醇 CD4＋CD25＋ T lymphocyte Preeclampsia Estriol
分类号 R714.246 [医药卫生—妇产科学]
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参考文献10

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同被引文献28

  • 1赵淑云,刘雨生.调节性T细胞及相关细胞因子与妊娠期高血压疾病[J].国外医学（计划生育．生殖健康分册）,2006,25(3):155-158. 被引量：4
  • 2葛均波,徐永健.内科学[M].8版.北京:北京人民卫生出版社,2013 :258-259.
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  • 7Cmara NO,Sebille F,Lechler RI. Human CD4 + CD25 + regulato-ry cells have marked and sustained effects on CD8 + T cell activa-tion [J]. Eur J Immunol,2003 ,33(12) :3483-3483.
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深圳中西医结合杂志
2012年 第4期

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