妊娠期高血压患者血液流变学与其并发症及围生儿结局的关系

Study on relationship between hemorheological changes and complications or perinatal outcomes in patients with pregnant hypertension syndrome

目的探讨妊娠期高血压患者血液流变学与其并发症及围生儿结局之间的关系。方法应用硫酸镁对2009年1月至2012年1月确诊为妊娠期高血压的孕妇689例进行治疗后,观察血液流变学指标控制理想者(A组,628例)和控制不理想者(B组,61例)之间并发症的差异及围生儿结局的差异。结果 A组没有一例患者出现并发症,B组中共有13例患者出现并发症,依次为胎盘早剥、弥散性血管内凝血、肾功能不全、HELLP综合征、脑血管意外。A、B两组早产儿、胎儿宫内发育迟缓、低体重儿、新生儿窒息、胎儿窘迫、围生儿死亡发生率比较均有显著性差异(P<0.01)。结论妊娠期高血压患者血液流变学监测对母婴并发症及围生儿结局的预测具有一定的临床意义。

Objective To explore the relationship between hemorheological changes and complications or perinatal outcomes in patients with pregnant hypertension syndrome. Methods Six hundred and eighty nine pregnant women with pregnant hypertension syndrome during January 2009 to January 2012 were treated with intravenous magnesium sulfate, 628 pregnant women with ideal control of hemorheological indices were allocated in group A and 61 pregnant women without ideal results were allocated in group B. The difference in occurrence of complications and perinatal outcomes among pregnant women in these two groups had been observed. Results Complication did not occur in patients of group A due to the ideal control of hemorheological indices, and complications were occurred in 13 patients of group B, their complications were arranged in order of frequency as abruptio placentae, DIC, renal insufficiency, HELLP（ hemolysis, elevated liver enzymes and low platelets）syndrome and cerebro- vascular accident. There were significant differences in occurrence of prematures, growth - retarded fetus, low weight neonates, neonatal suffoca- tion, fetal respiratory distress and perinatal mortality between these two groups （ P 〈 0.01 ）. Conclusion The detection of hemorheological indi- ces is important in clinical prediction of complications and perinatal outcomes in patients with pregnant hypertension syndrome.