摘要
用单克隆抗体进行肿瘤诊断治疗研究是目前解决肿瘤诊治的新途径。大量肿瘤动物模型、临床病例的定位研究表明,放射免疫定位(Radioimmuno-localization)结合了单抗特异性强、放射性同位素灵敏度高的优点,对肿瘤原发灶、转移灶的体内检测可能有着较好的前景。
The possible localization of antihuman small cell lung cancer(NCI-H128)monoelonalantibody (MAb) 2F7 (IgG2a) in tumor borne by nude mice was studied. When^(125)I-2F7 MAb was injected iv or ip, some good images was obtained without substraction.Tumor: nontumor ratio was 3.1 and 2.7 at 48 and 168 hours respectively after admini-stration. In biodistribution study the specific MAb 2F7 gave a tumor (cpm/g)/blood(cpm/g) ratio of 1.67, while all other tissues were below 0.5. According to the size,tumors were divided into two groups, everyone in one group was over 0.5g and inother below 0.5g. These two groups differed statistically in cpm% and cpm/g%. Thegood affinity between MAb 2F7 and H128 in vive suggested that MAb 2F7 could havepotential clinical application in tumor localization and targeting therapy.
出处
《肿瘤》
CAS
CSCD
北大核心
1990年第1期7-9,共3页
Tumor
