摘要
一些流行病学研究表明,高脂肪和低纤维素膳食是引起大肠癌的重要原因之一,并认为胆汁酸与大肠癌的发病机理有关。某些临床病例的对照研究发现,大肠癌患者粪便中含有高浓度的总胆汁酸和/或次级胆汁酸,但亦有报道未获得相似的结果。
The fecal bile acids were extraeted from 21 patients with large bowel(colonic andrectal)cancer and 21 controls,and the bile acid composition and concentration were measured by gas chromatography. The total bile acid concentration and concentrationof individual bile acids were not statistically different between colonic and rectalcancer. But the concentration and the percentage composition of secondary bile acids(deoxycholic and lithocholic acids)were significantly higher than that in controls.However the percentage composition of primary bile acids(cholic and chenocholic acids)were significantly lower than that in controls. The results suggest that incidence of largebowel cancer is closely related to the metabolism of fecal bile acids, and the etiology ofcolonic and rectal cancers may be the same.
出处
《肿瘤》
CAS
CSCD
北大核心
1990年第1期21-23,共3页
Tumor
基金
国家自然科学基金
