阻塞性睡眠呼吸暂停低通气综合征与急性脑梗死预后的关系研究

Study on the Relationship between Obstructive Sleep Apnea Hypopnea Syndrome and Acute Cerebral Infarction Prognosis

目的探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)对急性脑梗死患者预后的影响。方法选取74例急性脑梗死患者,根据多导睡眠仪(PSG)监测结果,将患者分为脑梗死合并OSAHS组(OSAHS组,44例)和单纯脑梗死组(对照组,30例)。对患者进行为期8年的随访,记录再次卒中和任何原因导致的死亡。比较OSAHS组和对照组无卒中事件生存情况,探讨OSAHS的严重程度是否与脑梗死及死亡率增加有关。采用SPSS 19.0统计软件进行分析。结果 OSAHS组患者无卒中事件生存概率低于对照组,差异有统计学意义(log-rank检验P=0.008)。趋势检验揭示随着睡眠呼吸暂停严重程度的加重,卒中复发或任何原因死亡的风险逐步增加(P=0.022)。结论脑梗死合并OSAHS与卒中复发的增加密切相关;OSAHS严重程度与不良预后风险增加相关。

Objective To study the influence of obstructive sleep apnea hypopnea syndrome （OSAHS） on the progno- sis of patients with acute cerebral infarction. Methods 74 patients with acute cerebral infarction were selected and were divided into OSAHS group （44 cases） and control group （ 30 cases） according to the monitoring results of polysomnography instrument （PSG）. The patients were followed up for eight years, and second - time stroke and death due to any reason were recorded. The survival without stroke of the OSAHS group and control group was compared and whether the severity of OSAHS is related to stroke and increased mortality was also discussed. SPSS 19.0 software was used to make analysis. Results The survival rate without stroke event in OSAHS group was significantly lower than that of the control group （ P = 0. 008, log - rank test）. Trend test showed that with the increasing of the severity of sleep apnea, the risk of stroke relapse or death due to any reason would also gradually increase （ P =0. 022）. Conclusion The combination of stroke with OSAHS is closely related to the increased relapse of stroke. The severity of OSAHS is related to the increased risk of poor prognosis.