摘要
三苯氧胺(TAH)为抗雌激素药物,用于妇科晚期肿瘤的内分泌治疗已取得明显的疗效。近年来,性激素与肝脏肿瘤的关系逐步引起大家的关注。一些作者用TAM等药物治疗临床肝癌病人和动物实验性肝肿瘤,也取得了一定的效果。有关肝肿瘤的内分泌治疗,国内还未见有报道。本实验用乙烯雌酚(DES)促发二乙基亚硝胺(DEN)引起大鼠肝肿瘤,同时TAM作为拮抗处理,最后通过测定肝胞浆内雌激素受体(ER),观察TAM对实验性肝肿瘤的影响,旨在评价肝肿瘤内分泌治疗的价值。
The effect of tamoxifen (TAM) on the liver tumorigenesis promoted by diethyl-stilbestrol (DES) and the changes of estrogen receptor (ER) in the liver cytoplasm inmale rat were investigated. All animals in treated group developed hepatocytic lesions(36.0%), neoplastic nodules (36.0%), and hepatocellular carcinoma(8.0%), confirmedby positive γ-GT (foci). But malignant transformation of liver tumors in TAM groupwas markedly lower than tumor group. The cytosol ER was defected by low capacity andhigh affinity with dextracoated charcoal (DCC). The ER contents in TAM group waslowest among the three groups. This suggested that TAM could inhibit the malignantransformation of the liver tumor by counteracting the activity of estrogen, and can berecommended for endocrine treatment of liver cancer in clinic.
出处
《肿瘤》
CAS
CSCD
北大核心
1990年第4期155-157,共3页
Tumor
