颅内肿瘤病人头发、血及脑脊液微量元素锰的测定意义

MANGANESE CONCENTRATION IN HAIR SERUM AND CEREBROSPINAL FLUID FROM PATIENTS WITH INTRACRANIAL TUMORS

微量元素与人体健康状况、疾病的发生有着密切关系。许多研究表明,锰(Mn)是一种抗癌元素,缺Mn与食管癌、直肠癌、鼻咽癌及肝癌等的发生有关,可是Mn与颅内肿瘤关系的报道则不多。本文通过测定颅内肿瘤病人的头发、血及脑脊液(CSF)中Mn的含量,以探讨它们的关系。

The concentrations of Mn in hair, serum and cerebrospinal fluid (OSF) from 44patients with intracranial fumors and from 20 control patients were measured. The hairMn and the CSF Mn concentrations decreased in both benign and malignant braintumors as compared with the controls (P<0. 01 and 0. 05 respectively). Serum Mu con-centration increased obviously only in malignant brain tumors. Hair, serum and CSFMn concentrations between meningioma and pituitary tumors had no significant differ-ence,nor did gliomas and metastases. It was postulated that decreases of hair and CSFMn and increase of serum Mn may suggest that Mu might participate in the genesisof brain tumors.