支气管哮喘患儿吸入丙酸氟替卡松疗效观察

Effect observation on the therapy of inhaling fluticasone propionate for asthma children

目的:观察哮喘患儿吸入丙酸氟替卡松(FP)治疗的疗效及评估哮喘控制水平。方法:(1)采用回顾性研究和临床随访的方法,选取在我院哮喘门诊就诊的哮喘患儿200例,按照哮喘控制简易方案(easyasthma management)进行病情严重程度分级,采取半随机自愿的形式(愿意接受激素治疗与拒绝激素治疗)分为两组,治疗组100例,根据病情程度给予FP治疗,非治疗组100例给予相关的对症治疗,疗程4周。治疗组在治疗2、4周后进行重新评估,比较治疗组在治疗前后日间及夜间症状评分改善情况,且以非治疗组同期观察哮喘控制情况作对比。(2)对200例哮喘患儿中≥4岁的98例检测峰流速(PEFR)值,对比治疗组在治疗前后此值变化情况及两组间该值对比情况。结果:(1)治疗组与非治疗组在年龄、性别、治疗前病情严重程度、日间及夜间症状评分均差异无统计学意义(P>0.05);治疗组在吸入FP治疗2、4周后各项症状评分均明显改善(P<0.001);治疗组与非治疗组2、4周后日间、夜间症状评分比较差异有统计学意义(P<0.001)。(2)治疗组在吸入FP 4周后PEFR值比治疗前明显改善(P<0.001),与非治疗组比较差异亦有统计学意义(P<0.001)。结论:吸入FP疗效明显,是目前较佳的支气管哮喘的治疗方法。

Objective： To observe the effect of inhaling fluticasone propionate（FP） for asthma children,and to evaluate asthma control level.Methods：（1） With the method of retrospective study and clinical follow-up,200 cases of asthma children were selected who ever came to asthma outpatient clinic in our hospital.Disease severity was classified according to easy asthma management.On a semi-random voluntary base,these 200 children were divided into two groups on average：treatment group and non-treatment group.FP therapy was given to treatment group,and non-FP therapy to another group,the treatment period was 4 weeks,same for both groups.In order to compare the symptom improvement in the daytime and nighttime in treatment group and to contrast the effect between the two groups,re-evaluation was made two and four weeks later.（2） Ninety-eight children,above 4 years old,whose peak expiratory flow rate（PEFR） was examined for contrasting the changes in the treatment group and between the two groups.Results：（1） there were no significant differences in age,sex,disease severity,daytime and nighttime symptom grading between the two groups before the treatment（P0.05）,after the FP treatment,the symptom grading made significant improvement two and four weeks later（P0.001）,but it made a significant difference between the two groups（P0.001）.（2） The PEFR of the treatment group improved significantly after two and four weeks（P0.001）,but the two groups had a significant difference on it（P0.001）.Conclusion： Inhaled corticosteroids therapy takes a significant effect,and it can be regarded as an excellent therapy for asthma.