淋巴毒素的抗肿瘤作用及白细胞介素2对其功能的影响

THE ANTITUMOR ACTIVITY OF LT AND THE EFFECT OF IL-2 ON IT'S FUNCTION

本文探讨了促有丝分裂原剌激淋巴细胞产生的含LT培养上清对肿瘤细胞的作用及IL2对其功能的影响、结果表明:含LT培养上清对多种人及小鼠的传代细胞,新分离的腹水瘤细胞及实体瘤细胞均有细胞毒性作用,放线菌素D能使这种作用增强,LT可增加人PBMC分泌LT;并能使其杀伤活性增加。

The effect of LT containing supernatant produced by lectin-stimulated human lymphocytes oa tumor cells and the relation between IL-2 and LT were studied in this article, results show that the LT containing suoernatants had cytotoxicities on many different kind of tumor, cells from human and mice, that actinomycin D increased the LT activities on target cells, and that LL-2 had the ability to increase the cytotoxicity of human PBMC on tumor cells, after being treated with LT, the target ceils were more easy to kill by PBMC as well. Combination of these two lymphokines could augment the antitumor activities of human PBMC greatly. These results suggest that these two lymohokines may be used as cancer therapeutie and prophylactic agents.