摘要
[目的]评价伽玛刀对原发性小肝癌的治疗疗效。[方法]2005年1月至2007年10月期间,无法行手术切除或拒绝手术切除的原发性小肝癌22例患者采用伽玛刀治疗。50%～70%等剂量曲线包绕PTV,(36～50)Gy/(8～12)f,(4～5)Gy/f,5f/w,平均照射剂量43.5Gy。用Kaplan-Meier分析生存率。[结果]CR4例(18.18%),PR12例(54.55%),SD4例(18.18%),PD2例(9.09%),总有效率为72.73%(16/22)。1、2、3年生存率分别为81.2%、68.7%和62.4%。中位生存时间40.0个月。治疗副反应轻微,无严重放射性肝损伤发生。[结论]伽玛刀对原发性小肝癌患者的治疗安全、有效,毒副反应较小,放射反应可耐受。
[Purpose] To evaluate the efficacy of γ-knife for small hepatocellular carcinoma（SHCC）.[Methods] During Jan 2005 to Oct 2007,22 cases with SHCC which were inoperable or refusing to surgical treatment were included and treated by γ-knife radiotherapy.Patients were treated with（36~50） Gy/（8~12） f,（4~5）Gy/f,5f/w,prescribed to the PTV-encl.（50%~70%）-isodose.The cumulative survival rates were analyzed by Kaplan-Meier method.[Results] CR was attained in 4 cases（18.18%）;PR,12（54.55%）;NC,4（18.18%） and PD,2（9.09%）.Overall response rate was 72.73%（16/22）.The 1-,2-and 3-year survival was 81.2%,68.7% and 62.4% respectively.The median survival time was 40.0 months.The treatment toxicity was mild and there was no serious radiation liver injury.[Conclusion] γ-knife for SHCC is safe,feasible,low toxicity and to be tolerated.
出处
《中国肿瘤》
CAS
2012年第8期627-630,共4页
China Cancer
关键词
肝肿瘤
立体定向放射治疗
伽玛刀
疗效
hepatocellular carcinoma
stereotactic radiation therapy
γ-knife
efficacy
