胃癌的手术和术后化疗综合治疗—附170例五年随访材料分析

Surqery Combined with Postoperative Chemotherapy in Stomach Cancer:An Analysis of 5—year Follow-up

本文报道我院1975～1982年收治的胃癌170例进行了胃癌手术+术后化疗综合治疗和单纯手术(对照组)的随机对照研究,并作了5年随访。治疗结果:胃癌术后化疗综合治疗组的5年生存卒为40.2％(33/82),明显高于单纯手术(对照组)的21.6％(19/88)(P<0.01)。综合治疗组的中位生存期为39月,优于对照组18月。在胃癌根治术后化疗综合治疗组的5年生存率为56.4％(31/55),亦明显高于单纯根治术组的30.2％(19/63),经统计学处理有显著差异(P<0.01)。根治本后化疗综合治疗组的中位生存期为45月,明显高于单纯根治术组的23月。在Ⅱ～Ⅲ期胃癌的根治术后化疗综合治疗5年生存率达60.5％(26/43较单)纯根治术组的36.9％(17/46)明显提高(P<0.05)。我们认为胃癌根治术后辅助化疗可能是提高胃癌术后长期生存的有效方法。

During the period of 1975-1985, 170 patients with stomach cancer were treated by surgery plus chemotherapy or surgery alone randomly. After 5-year followup, the results are pre-sent as follows: 5—year survival rate for combinative therapeutic group was 40.2％ (33/82), for contol group was 21.6％ (19/88), P<0.01. The median survival time for former group was 39 months, for latter was 18 months only. The five year survival rate and the median survival time for the patients who treated by radical operation and chemotherapy were 56.4％ (31/55) and 45 months respectively,but for control group were 30.2％ (19/63) and 23 months (P<0.01). The 5-year survival rate for patients with Stages Ⅱ or Ⅲ, the combinative therapeutic group was 60.5％ (26/43), the control group was 36.9％ (17/46). These results suggested that radical operation combined with chemotherapy would be an effecitve method to enhance the survival time.