小剂量顺铂治疗晚期卵巢癌

LOW—DOSE CIS—DDP IN ADVANCED OVARIAN CARCINOMA

本组自1975年应用小剂量多疗程顺铂治疗Ⅲ、Ⅳ期卵巢癌截止1985年底共46例。单用顺铂21例;以顺铂为基础的联合化疗25例:寿命表法计算46例晚期癌3、4和5年存活率为45.4％、41.9％和35.4％。毒副反应轻微,未曾发生严重肾毒和神经毒性。本文还就小剂量顺铂对机体免疫功能影响进行了探讨。

Between 1975 to 1935, 46 patients with stages Ⅲ and iv ovarian cancer were treated by low-dose multiple courses of Cis-DDp. Among tile patients, 21 cases were treated singly with Cis-DDp and 25 cases with Cis-DDp-based combined ckemotherapy. Sinqle Cis-DDp group Cis-DDp 20-30mg/day iv qod 5 times for each eoures. Ten to fifteen treated cottrsewere given` and 3-, 4-and 5-year survival rate of 46 cases were 45.4％, 41.9％ and 35.4％ respectively. The toxic and side effects were min imal, no severe nephrotoxieity or severe n ttrotoxicity were ocettred. The effect of low-dose Gis-DDp on body immunization are also diseaseed in this paper.