基于聚类分析的元代以前角膜炎组方规律研究

Studying Regular Pattern of Medication in Formation of Formula for Treatment of Keratitis before Yuan Dynasty by Cluster Analysis

基于聚类分析与中医古籍文献整理相结合的方法,对元代以前角膜炎治疗方药进行整理分析,挖掘出13组角膜炎常用聚类药物群。分析显示,其治法以疏风、清热、利湿、泻火、解毒、化痰、解郁为治标,以益气、滋阴、养血为固本,据此推断发病机制以风、湿、热、火、毒、痰、郁为标实,以气、阴、血亏为本虚。聚类分析结果较客观地反映了该时期角膜炎组方用药规律,为临床辨证论治提供新思路。

we collected, put in order and analyzed the formulae and drugs on treating keratitis before Yuan dynasty by cluster analysis combined with ancient TCM records literature, and dig out 13 groups of cluster drug on keratitis commonly used. Among them the treatment methods included dispelling wind, clearing heat, removing dampness, purging fire, neutralizing poison, dissipating phlegm and eliminating depression to treat the appearance, and tonifying qi, nourishing yin, and nourishing blood to get at the root. According to it we deduced that its pathogenesy is sthenia in superficiality because of wind, wetness, heat, fire, poison, phlegm and depression, and asthenia in origin because of deficiency of qi, yin and blood. The cluster analysis results reflected objectively the regular pattern of medication and prescription on keratitis in that period, and provided a new thinking way for differentiation and treatment of keratitis in clinic.