摘要
本文报道自1958年至1988年底于中国医学科学院肿瘤医院治疗的有完整临床及病理资料的10例子宫内膜间质肉瘤。参照组织学分类标准,10例均属于淋巴管内间质异位症(低度恶性子宫内膜间质肉瘤)。发病年龄平均为40.5岁。临床分期为Ⅰ期8例,Ⅱ期1例,Ⅲ期1例,其中Ⅰ期4例,Ⅱ期1例于术中发现肿瘤已播散至子宫以外。10例中8例行全子宫及救附件切除术,1例行全子宫单侧附件切除术,1例于外院手术仅行子宫次全切除术。术前辅以腔内治疗者2例,术后盆腔体外放疗6例,均达放射治疗剂量,术后化疗2例。10例中有2例复发,其中1例治疗后13年复发,经化疗后稳定,于复发后2年仍存活。1例于术后4年复发,经放射治疗后稳定,复发后6年仍存活。其中5例随访达5年以上,其5年及10年存活率均达100%。
We reviewed 10 cages of endometrial stromal tumorg treated in Cancer Institute (Hospital), Chinese Academy of Medical Sciences from 1958 to 1988. All 10 patients had endolymphatic stromal myosis (ESM) (Low-grade endometrial stromal tumors). Mean age was 40.5 years. Eight patients were stage Ⅰ, one patient was stage Ⅱ and one patient had stage Ⅲ disease. Laparotomies revealed extrauterine spread in five patients wish stage Ⅰ or Ⅱ. Primary surgery was received, in all 10 patienst. Total abdominal hysterecsomy aodbilateral salpingo-oophorectomy was performed in 8 patients. Following hysterectomy; 8 patients received various adjuvant therapies. Twn Patients had recurrences at 4-yeart and 10 years after primary therapy respectively, and receivedtchometherapy crradiation. Objective responses were attained and the survival following treatment of recurrent disease was 2 years and 6 years respectively. It shows that even ESM is a malignant disease clinically but is a low-grade malignant tumor histologically, Treatment has been primarly surgical as well as adjuvant radiation and chemotherapy. Long period follow-up should be recommended.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
1990年第4期195-199,共5页
Cancer Research on Prevention and Treatment