子宫内膜增生过长与内膜腺癌超微结构的立体学形态计量研究——细胞成分结构参数的分析

STEREOLOGIC MORPHOMETRIC STUDY ON ULTRASTRUCTURE OF ENDOMETRIAL HYPERPLASIA AND ADENOCARCINOMA

本文运用立体学方法对增殖期子宫内膜、囊腺型、腺瘤型增生及高分化内膜腺癌各5例的超微结构进行形态计量研究,结果表明:在内膜细胞癌变过程中细胞器经历了代偿性增生和退行性改变两个发展阶段。在增生阶段由于雌激素的过度刺激,细胞器代偿性增生,代谢活动增强,随细胞分化程度的降低,细胞器逐渐失去对雌激素的生理反应,出现退行性改变及代谢途径的改变。立体学形态计量法能够更精确、客观地反应内膜细胞的变化特征。

Ultrastructure of normal proliferative endometrium, cystic and adenomatous hyperplasia as well as well-differentiated endometrial carcinoma (5 cases for each group) were studied bystereologic morphometry. The results showed that with endometrial cell passing through its course of evolution to carcinoma, organelles of the cells probably first exhibited functional compensatory changes so as to fulfill the need of rapid cell proliferation and accelerated matabolism As the course went further, many organelles in which physiological reaction to estrogen was progressively lost presented degenegation in morphology. In our opinion, the stereologic morphometry could reflect morphologic cheracteristics of endometrium more objectively and prccisely.