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紧密连接与自身免疫性疾病

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摘要 自身免疫性疾病的发病机制相当复杂,为多种因素共同作用所致。近年来的研究发现,除了人们普遍认同的环境因素、遗传因素以外,肠道通透性增加可能也是自身免疫性疾病的发病机制之一。研究者发现,在乳糜泻、Ⅰ型糖尿病和炎症性肠病的发病过程中,肠道通透性增加往往发生在疾病发生之前,其引起的异常的抗原提呈激活免疫系统,最终可能引起自身免疫性疾病的发生。
作者 潘璠 刘成霞
出处 《滨州医学院学报》 2012年第3期223-225,共3页 Journal of Binzhou Medical University
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