肥胖与代谢综合征患者血清lipocalin-2、hsCRP变化

A Study on the Changes of Serum Lipocalin-2 and High Sensitive C Reactive Protein Levels and Their Relationship in Obese Patients and Metabolic Syndrome Patients

目的:探讨肥胖、代谢综合征患者血清中性粒细胞明胶酶相关脂质运载蛋白2(lipocalin-2,LCN2)、超敏C反应蛋白(hsCRP)的变化及其相关性。方法:选择104例正常体重者、107例超重者和52例肥胖者进行体格检查、口服葡萄糖耐量试验及血脂、胰岛素(FINS)、hsCRP、lipocalin-2检测;计算胰岛素抵抗指数(HOMA-IR)。结果:(1)肥胖患者血清lipocalin-2增高,校正年龄和性别后,血清lipocalin-2水平与体重指数(BMI)、腰围、体脂含量、hsCRP正相关(P<0.05),与HDL-C水平负相关(P=0.001);(2)校正年龄、性别和BMI后,血清lipocalin-2水平仍与hsCRP正相关(P<0.05),与HDL-C水平负相关(P=0.023);多元逐步回归分析显示,hsCRP是血清lipocalin-2的独立决定因素;(3)代谢综合征患者lipocalin-2水平增高,但lipocalin-2与代谢紊乱数目未见显著性关联。结论:肥胖与代谢综合征患者血清lipocalin-2和hsCRP均增高,且lipocalin-2水平与hsCRP正相关。lipocalin-2可以作为肥胖相关低度炎症的新的标志物。

Objective： To explore the changes of serum lipocalin-2（LCN2） and high sensitive C reactive protein（hsCRP） levels and their correlation in obese patients and metabolic syndrome（MS） patients.Methods： Total 104 normal control subjects,107 overweight subjects and 52 obese patients were selected.Physical examination and oral glucose tolerance test（OGTT） were performed in the three groups,and serum lipid,fasting insulin,hsCRP,serum lipocalin-2 levels were measured.Insulin resistance index（HOMA-IR） was calculated.Results：（1）The lipocalin-2 levels of obese patients were higher than those of normal controls and overweight subjects.After adjusting age and sex,lipocalin-2 level was positively correlated with BMI,waist circumference（WC）,body fat content and hsCRP level（P0.05）,but was negatively correlated with HDL-C level（P=0.001）.（2）After adjusting sex,age and BMI,lipocalin-2 level was also positively correlated with hsCRP level（P0.05） and was negatively correlated with HDL-C level（P=0.023）.Multiple stepwise regression analysis demonstrated that hsCRP was independent determinant for lipocalin-2 level.（3）Lipocalin-2 level increased in MS patients,but was not significantly associated with the numbers of metabolic disorders.Conclusions： Serum lipocalin-2 and hsCRP levels significantly increase in obesity patients and MS patients.Lipocalin-2 level positively correlates with hsCRP level.Lipocalin-2 might be a useful new marker for evaluating obesity-related low-grade inflammation.