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IL-23R基因多态性及其与疾病易患性的研究进展 被引量：2

Research Progress of IL-23R Gene Polymorphism and Susceptibility to the Diseases
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摘要 白细胞介素23受体(IL-23R)是其复合物的两个亚基之一。IL-23在炎性反应、自身免疫性疾病、肿瘤等方面发挥着重要作用。IL-23R的主要功能是介导IL-23在细胞内的信号转导。IL-23-IL-23R途径是机体炎性反应中的重要部分,也是一个潜在的促进恶性肿瘤发展的路径。IL-23R的遗传多态性已被证实与某些炎症性疾病、自身免疫疾病和恶性肿瘤相关。IL-23R遗传特性的研究为进一步明确疾病的发病机制提供了理论基础。 Interleukin-23 receptor（IL-23R） is one of the two subunits of IL-23 receptor complexes.IL-23 plays an important role in inflammation,autoimmune disease and tumor.The main function of IL-23R is mediating IL-23 intracellular signal transduction.The IL-23-IL-23R pathway is not only an important part in the inflammatory response,but also a potential path to promote tumor development.IL-23R genetic polymor-phism has been shown to be associated with certain inflammatory diseases,autoimmune diseases and malignant tumors.The research on the genetic characteristics of IL-23R has provided theoretical basis to further clarify the disease pathogenesis.
作者 覃彦平 秦雪
机构地区 柳州市红十字会医院检验科 广西医科大学 广西医科大学第一附属医院临床实验中心
出处 《医学综述》 2012年第16期2564-2567,共4页 Medical Recapitulate
基金 广西自治区卫生厅自筹经费科研课题(22012548)
关键词 白细胞介素23受体 遗传 多态性 Interleukin-23 receptor Genetic Polymorphism
分类号 R392.12 [医药卫生—免疫学]
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参考文献25

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二级参考文献11

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医学综述
2012年 第16期

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