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Pim-1基因表达与肿瘤相关性的研究进展 被引量：7

Research Progress of the Relationship Between Pim-1 Expression and Tumors
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摘要 原癌基因Pim-1定位在第6号染色体长臂上(6p21.1～p21.31),其表达产物Pim-1蛋白激酶具有丝氨酸/苏氨酸蛋白激酶活性。Pim-1可抑制细胞凋亡,与肿瘤的发生密切相关。在某些恶性肿瘤中存在Pim-1高表达,虽然Pim激酶家族在细胞增殖、分化、存活方面发挥重要作用,但要阐明Pim-1表达与肿瘤发生的相关性仍需进一步深入研究。 Proto-oncogene Pim-1 locates in the long arm of chromosome No.6（6p21.1-p21.31）,Pim-1 protein kinase has serine/threonine protein kinase activity.Pim-1 may inhibit apoptosis,and is closely related with tumorigenesis.It is reported that Pim-1 is highly expressed in some malignant tumors.Pim kinase family plays a crucial role in cell proliferation,differentiation and survival,however,further research is still needed to clarify the correlation between Pim-1 expression and tumorigenesis.
作者 丁昭珩 丁罡
机构地区 上海交通大学医学院附属新华医院崇明分院肿瘤科
出处 《医学综述》 2012年第16期2584-2586,共3页 Medical Recapitulate
关键词 Pim-1基因 丝/苏氨酸激酶 肿瘤 细胞凋亡 Pim-1 gene Serine/threonine kinase Tumor Apoptosis
分类号 R730.53 [医药卫生—肿瘤]
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参考文献7

二级参考文献54

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共引文献26

同被引文献82

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引证文献7

二级引证文献12

医学综述
2012年 第16期

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