血塞通注射液对慢性阻塞性肺疾病急性加重期患者血液流变学等相关因素的影响

Effect of Xuesaitong Injection on Hemorheology and Other Related Factors in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

目的观察血塞通注射液对慢性阻塞性肺疾病急性加重期(AECOPD)患者血液流变学等相关因素的影响。方法 70例AECOPD合并血液流变学指标异常患者,随机分成治疗组和对照组各35例,两组患者均予常规的抗感染、祛痰、解痉、平喘、纠正水电解质紊乱、氧疗等综合治疗。治疗组在上述治疗的基础上加用血塞通注射液0.4 g+5%葡萄糖溶液250 mL中静脉滴注,每日1次。共14 d。观察两组患者治疗前后血液流变学指标的变化并同时进行呼吸困难评分,6分钟步行距离测定。结果治疗组的血液流变学各项观察指标均较治疗前明显下降,差异有统计学意义(P<0.05),呼吸困难评分,6分钟步行距离指标有所改善,但差异无统计学意义(P>0.05)。结论血塞通注射液可降低血黏度,改善微循环,有利于病情改善。

Objective To observe effect of Xuesaitong injection on hemorheology and other related factors in patients with acute exacerbation of chronic obstructive pulmonary disease（AECOPD）.Methods 70 cases of AECOPD patients with abnormal hemorheology indices,were randomly divided into treatment group and control group,respectively in 35 cases.All patients were given combined therapy such as conventional anti-infection,expectorant,antispasmodic,correcting water and electrolyte disturbance,and oxygen treatment,on the basis of which,the treatment group was given extra Xuesaitong injection of 0.4g＋ 5% glucose solution 250 mL intravenously,1 time a day,14 days in total.Hemorheology change after treatment and dyspnea score,6 minute walk distance determination were observed or tested.Results Hemorheology and the observed indicators of the treatment group decreased significantly（P0.05）after treatment;dyspnea score and 6 minutes walking distance indicator have improved,though the differences were not statistically significant（P0.05）.Conclusion Xuesaitong can reduce blood viscosity and improve microcirculation,which is helpful for the illness condition improvement.