HIF-1α和VEGF在膀胱移行细胞癌中的表达及其相关性

Expression and Correlation of HIF-1α and VEGF in Bladder Transitional Cell Carcinoma

目的探讨缺氧诱导因子1α(HIF-1α)与血管内皮生长因子(VEGF)在膀胱移行细胞癌中的表达、临床意义及两者的相关性。方法采用免疫组织化学SP法检测52例膀胱移行细胞癌和10例正常膀胱黏膜组织中HIF-1α和VEGF的表达。结果膀胱移行细胞癌组织中HIF-1α和VEGF的阳性表达率分别为51.9%和57.7%,与对照组相比具有统计学意义(P<0.05)。HIF-1α和VEGF的表达与肿瘤的病理分级、临床分期呈正相关(P<0.05),两者之间呈显著正相关(rs=0.406,P<0.05)。结论 HIF-1α和VEGF表达对膀胱癌生物学行为有重要影响。

Objective To explore the expression and clinical significance of HIF-1α and VEGF and the correlation of the two factors in bladder transitional cell carcinoma（BTCC）.Methods SP method of immu-nohistochemistry was used for detecting the expression of HIF-1α and VEGF in mucosa of 52 BTCC samples and 10 normal controls.Results HIF-1α and VEGF positive rates were 51.9% and 57.7% of BTCC sam-ples,respectively,which were significantly different compared with the control group（P0.05）.The expression of HIF-1α and VEGF had positive correlation with pathologic grades and clinical stages（P0.05）.Andthe expression of the two factors had positive correlation with each other（rs=0.406,P0.05）.Conclusion HIF-1α and VEGF expression have a significant effect on the biological behavior of BTCC.