肿瘤微环境影响卵巢癌生物学行为的研究进展

Tumor Microenvironment Affecting Biological Behaviour of Malignant Ovarian Neoplasms: an Update

肿瘤微环境是一个由肿瘤细胞、基质细胞、细胞因子、免疫细胞等共同构成的肿瘤局部的病理环境,具有组织缺氧、酸中毒、间质高压等特点。肿瘤微环境中大量的生长因子、蛋白水解酶以及免疫炎性反应共同作用于肿瘤细胞表面,对细胞的增殖、转移、分化等产生重要影响。卵巢癌早期症状不典型、转移迅速,预后差,已成为严重威胁妇女健康的肿瘤之一。综述肿瘤微环境与卵巢癌恶性生物学行为的关系。

The tumor microenvironment is a tumor cell,stromal cells,cytokines,immune cells such as tumor constitute the environment of local pathology,which is tissue hypoxia,acidosis,interstitial high pressure and so on.In tumor microenvironment in a large number of growth factors,proteolytic enzymes and the immune inflammatory response which interact on the tumor cell surface,play an important impact on cell proliferation,metastasis,differentiation.Early symptoms of ovarian cancer because of its atypical metastatic quickly,so the prognosis is poor,has become one of the serious threat to women′s health tumor.In this paper the tumor microenvironment and the malignant behavior of ovarian cancer combined with each other,are reviewed.