格列苯脲治疗妊娠期糖尿病

Glyburide for the Treatment of Gestational Diabetes Mellitus

妊娠期糖尿病(GDM)是妊娠期最常见的合并症之一,妊娠期血糖的稳定情况可影响妊娠结局。目前国内临床上对于GDM的治疗,除饮食控制、运动锻炼控制外,主要依靠注射胰岛素,较少应用口服降糖药。目前一些动物试验和临床试验的研究表明,格列苯脲作为一种常用的口服降糖药,在GDM的治疗中未发现致畸作用,其在国外GDM的临床治疗中应用日益增加。通过文献复习,评论格列苯脲在GDM治疗中的应用。

Gestational diabetes mellitus is one of the most common complications during pregnancy.The control of blood sugar impacts on maternal and fetal outcome of pregnancy.Currently,it usually gives the patients with diet and exercise to control the blood sugar in our clinical practice.If it can not work,insulin will be used.There is rarely oral hypoglycemic medication being used in clinical practice in gestational diabetes mellitus.Glibenclamide used as a commonly used oral hypoglycemic agents has not been found teratogenic effects in the present animal experiments and clinical trials.The clinical application is increasing in foreign countries.This article will discuss the applications of glibenclamide in gestational diabetes mellitus.