期刊文献+

一种基于受体编辑的实值阴性选择算法 被引量:2

Receptor Editing-inspired Real Negative Selection Algorithm
下载PDF
导出
摘要 受生物免疫受体编辑理论的启发,提出了一种基于受体编辑的实值阴性选择算法RERNS(Receptor Editing-inspired Real Negative Selection Algorithm)。对于匹配自体的检测器,该算法采用定向受体编辑使之获得新生,而这些新生的检测器分布在自体与非自体的边界区域,从而增加了检测器的多样性,并改善了算法对边界区域的覆盖情况;对于不匹配自体的检测器,该算法采用识别相同最近自体的定向受体编辑,使检测器在包含原检测范围的情况下扩大了对非自体空间的覆盖。理论分析和实验验证表明,与实值阴性选择算法中具有代表性的RNS算法和V-detec-tor算法相比,RERNS算法生成的未成熟检测器更少,且检测性能更好。 Inspired by theory of biological immune receptor editing,a receptor editing-inspired real negative selection algorithm(RERNS) was proposed.For the detector that matches self,algorithm uses directional receptor editing to make a new life.These new detectors are located in the area of self and non-self boundary,thereby the diversity of detector is increased and the boundary covered by the algorithm is also improved.For the detector that does not match self,algorithm uses direction receptor editing for identifying identical nearest self to expand coverage of no-self space under the circumstances of containing original scope of detector.Theoretical analysis and experimental verification show that RERNS algorithm generates less un-mature detectors and obtains better detection performance than the most representa-tive RNS algorithm and V-detector algorithm.
作者 李贵洋 郭涛
出处 《计算机科学》 CSCD 北大核心 2012年第8期246-251,共6页 Computer Science
基金 四川省科技厅重点实验室项目(PJ201102)资助
关键词 人工免疫系统 阴性选择算法 受体编辑 Artificial immune system Negative selection algorithm Receptor editing
  • 相关文献

参考文献13

  • 1Forrest S,Perelson A S, Allen L, et al. Self-nonself discrimina- tion in a computer[C]//Proceedings of IEEE Computer Society Symposium on Research in Security and Privacy. Los Alamitos: IEEE Computer Soc Press, 1994 : 202-212.
  • 2Forrest S, Beauchernin C. Computer immunology[J]. Immunol Rev, 2007,216(1) : 176-197.
  • 3Timmis J. Artificial inunune systems--today and tomorrow[J]. Natural Computing, 2007,6(1) : 1-18.
  • 4Balthrop J, Esponda F, Forrest S, et al. Coverage and generaliza- tion in an artificial immune system[C]//GECCO 2002. New York: Morgan Kaufmann Publishers Inc, 2002 : 3-10.
  • 5张衡,吴礼发,张毓森,曾庆凯.一种r可变阴性选择算法及其仿真分析[J].计算机学报,2005,28(10):1614-1619. 被引量:43
  • 6何申,罗文坚,王煦法.一种检测器长度可变的非选择算法[J].软件学报,2007,18(6):1361-1368. 被引量:24
  • 7Gonzalez F, Dasgupta D, Gomez J. The effect of binary matching rules in negative selection[C]//GECCO 2003. Chicago: Springer Berlin, 2003 : 196-206.
  • 8Ji Z, Dasgupta D. Real-valued negative selection algorithm with variable-sized detectors [C] // GECCO 2004. Washington: Springer Berlin, 2004: 287-298.
  • 9Ji Z. A boundary-aware negative selection algorithm[C]// The Ninth IASTED. Benidorm: Acta Press, 2005 : 29-42.
  • 10Ji Z,Dasgupta D. Estimating the detector coverage in a negative selection algorithm [C]//GECCO 2005. Washington: ACM Press, 2005 : 281-288.

二级参考文献41

  • 1贺龙涛,方滨兴,余翔湛.一种时间复杂度最优的精确串匹配算法[J].软件学报,2005,16(5):676-683. 被引量:25
  • 2张衡,吴礼发,张毓森,曾庆凯.一种r可变阴性选择算法及其仿真分析[J].计算机学报,2005,28(10):1614-1619. 被引量:43
  • 3龙振洲.医学免疫学[M].北京:人民卫生出版社,1995..
  • 4FinK PJ, McMahan CJ. Lymphocytes rearrangement, edit and revise their antigen receptors to be useful yet safe. Immunol Today, 2000, 21(11): 561-566.
  • 5Ali M, Weinreich M, Balcaitis S, et al. Differential regulation of peripheral CD4 + T cell tolerance induced by deletion and TCR revision. J Immunol, 2003, 171 ( 11 ) : 6290-6296.
  • 6McMahan C J, Fink PJ. Receptor revision in peripheral T cells creates a diverse V beta repertoire. J lmmunol, 2000, 165 (12) : 6902-6907.
  • 7Papavasiliou F, CaseUas R, Suh H, et al. V(D)J recombination in mature B cells: a mechanism for altering antibody responses. Science, 1997, 278(5336): 298-301.
  • 8Hertz M, Kouskoff V, Nakamura T, et al. V (D) J recombinase induction in splenic B lymphocytes is inhibited by antigen-receptor signalling. Nature, 1998, 394(6690) : 292-295.
  • 9Thai TH, Kearney JF. Isoforms of terminal deoxynucleotidyl transferase: developmental aspects and function. Adv Immunol, 2005, 86: 113-136.
  • 10Santori FR, Arsov I, Lilic M, et al. Editing autoreactive TCR enables efficient positive selection. J Immunol, 2002, 169 (4): 1729-1734.

共引文献56

同被引文献13

  • 1李涛.基于免疫的计算机病毒动态检测模型[J].中国科学(F辑:信息科学),2009,39(4):422-430. 被引量:11
  • 2张衡,吴礼发,张毓森,曾庆凯.一种r可变阴性选择算法及其仿真分析[J].计算机学报,2005,28(10):1614-1619. 被引量:43
  • 3Forrest S,Perelson A S,Allen L, et al. Self-nonself Discrimination in a Computer [C]//Proceedings of the 1994IEEE Symposium on Research in Security and Privacy. Los Alamitos, CA: IEEE Press, 1994: 202-212.
  • 4Gonzalez F,Dasgupta D,Kozma R. Combining Negative Selection and Classification Techniques for AnomalyDetection [C]//Proc the 2002 IEEE Congress on Evolutionary Computation, CEC-2002. Honolulu: IEEE, 2002 :705-710.
  • 5Laurentys C A, Palhares R M, Caminhas W M. A Novel Artificial Immune System for Fault Behavior Detection[J]. Expert Systems with Applications, 2011, 38: 6957-6966.
  • 6XU Aiqiang,LIU Yong,ZHAO Xiuli, et al. Optimization and Application of Real-Valued Negative SelectionAlgorithm [J]. Procedia Engineering, 2011, 23: 241-246.
  • 7LIU Fang, GONG Maoguo, MA Jingjing, et al. Optimizing Detector Distributionin V-Detector Negative SelectionUsing a Constrained Multiobjective Immune Algorithm [C]//2010 IEEE Congress on Evolutionary Computation(CEC). Barcelona, Spain: IEEE, 2010: 1-8.
  • 8Heydenrych M, Ehlers E. A Charged PSO Inspired Method for Generating Immune Detectors for NetworkIntrusion Detection [C]//2011 IEEE 10th International Conference on Trust, Security and Privacy in Computingand Communications (TrustCom). [S. L ] t IEEE, 20111 134-141.
  • 9WANG Dawei, ZHANG Fengbin, XI Liang. Evolving Boundary Detector for Anomaly Detection [J]. ExpertSystems with Applications, 2011, 38: 2412-2420.
  • 10罗微,马骊,王小宁.T细胞受体编辑与修正[J].中华微生物学和免疫学杂志,2008,28(3):278-281. 被引量:4

引证文献2

二级引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部