胎儿鼻骨发育异常与唐氏综合征相关性研究

Study on correlation between fetal nasal dysplasia and Down's syndrome

目的:探讨鼻骨发育异常与唐氏综合征的相关性,评价其在产前诊断中的意义。方法:利用超声对3 850例因各种高危因素行羊水穿刺的胎儿行鼻骨测量检查。结果:正常胎儿的鼻骨随孕周增加而增长,鼻骨长度与孕周成直线相关关系(r=0.67,P<0.05)。31例唐氏儿鼻骨缺失或鼻骨发育不良发生率为67.7%(21/31),鼻骨缺失19例,鼻骨发育不良4例(<0.20 cm)。结论:鼻骨发育异常与唐氏综合征有密切关系,鼻骨的检查是筛查唐氏综合征的一项重要指标。

Objective： To explore the correlation between fetal nasal dysplasia and Down＇s syndrome, evaluate its significance in prenatal diagnosis. Methods： Ultrasound was used to measure and examine nasal bones of 3 850 fetuses undergoing amniocentesis because of various high risk factors. Results： Nasal bones of normal fetuses lengthened with gestational weeks, there was a linear correlation between the length of nasal bone and gestational weeks （y =0. 67, P 〈0. 05） . Among 31 fetuses with Down~ syndrome, the incidence of nasal bone loss or nasal dysplasia was 67.7% （21/3I）, 19 fetuses with nasal bone loss and 4 fetuses with nasal dysplasia were included （ 〈0. 20 cm） . Con- clusion ： Nasal dysplasia is closely related to Down~ syndrome, nasal examination is one of the important indexes for screening Down~ syn- drome.