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单核细胞趋化蛋白在子宫内膜癌的表达和临床意义 被引量:4

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摘要 目的:单核细胞趋化蛋白在子宫内膜癌中的表达情况及其临床意义。方法:利用免疫组织化学染色、RT-PCR及蛋白免疫印迹等方法对子宫内膜癌中的单核细胞趋化蛋白表达情况进行了研究,探讨单核细胞趋化蛋白与子宫内膜癌的相关性。结果:子宫内膜癌组织中的MCP-1的表达阳性率明显高于正常子宫内膜组织和增生性子宫内膜组织(P<0.05)。另外,对不同类型子宫内膜组织中MCP-1 mRNA的表达情况进行比较,发现子宫内膜癌组织中的MCP-1 mRNA水平明显高于正常子宫内膜组织和增生性子宫内膜组织。子宫内膜癌细胞EFE-184中MCP-1蛋白表达水平明显高于正常子宫内膜细胞。结论:子宫内膜癌组织中单核细胞趋化蛋白在mRNA和蛋白水平均表达明显增强,单核细胞趋化蛋白对子宫内膜癌的发病及进展均有一定的促进作用。
作者 郑晓霞
出处 《中国妇幼保健》 CAS 北大核心 2012年第26期4116-4117,共2页 Maternal and Child Health Care of China
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  • 1American society for reproduction medicine. Revised American society for reproductive medicine classincation of endometriosis 1996 [ J 1. Fetil Steril, 1997,67 (4) : 817-821.
  • 2Mrata A, Arata S, Nose K. Involement of reactive oxygen spesis in the induction of chemokine JE? MCP-1 gene by phobol-12-myristate -13-acetate in Balb 3T3 ceils[J]. Cell Struct Funct, 1997,22 (3) : 231-238.
  • 3Yih S, Katabuehi H, Araki M,et al. Expression of monoeyte chemoat tractant protein-1 in peritoneal indometriotic cells [J]. Virchows Arch,2001,438 (4) :70-77.
  • 4Akoum A, Lemay A, McColl S, et al. Elevated concentration and biologic activity of monocyte chemotactic protein-1 in the peritoneal fluid of patients with endometriosis [ J]. Fertil Steril, 1996,66 (1) :17- 23.
  • 5Arici A, Oral E, Attar E, et al. Monocyte chemotactic prote in-1 concentration in peritoneal fluid of women with endometriosis and its modulation of expression in mesothelial cells [ J ]. Fertil Steril, 1997,67 ( 6 ) : 1065-1072.
  • 6Akoum A, Lemay A, McColl SR, et al. Increased monocyte chemotactic protein-1 level and activity in the periphera 1 blood of women with endometriosis [ J ]. Am J Obstet Gynecol, 1996,66 ( 5 ) : 175- 176.
  • 7Mayo MW,BaLdwin AS.The transcription factor:controL of oncogenesis and cancer therapy resistance[J].Biochemi Biophys Acta,2000,1470:M55.
  • 8Kumar SN,Boss JM.Site A of the MCP-1 distaL reguLatory region functions as a transcriptionaL moduLator through the transcription factor NF1[J].MoL ImmunoL,2000,37(11):623.
  • 9Boekhoudt GH,Guo Z,Beresford GW,et al.Communication between NF-kappa B and Sp1 controLs histone acetyLation within the proximaL promoter of the monocyte chemoattractant protein 1 gene[J].J ImmunoL,2003,170(8):4139.
  • 10Yih S, Katabuchi H, Araki M, et al. Expression of monocyte ehemoat tractant protein-1 in peritoneal indometriotie cells. Virchows Arch, 2001, 438:70-77.

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  • 1潘佩英,李惠,徐韬,尤佳.NF-κB、P53蛋白在子宫内膜癌中的表达及意义[J].贵州医药,2011,35(4):301-303. 被引量:1
  • 2张瑞,王选.大鼠急性胰腺炎中核因子NF-κB抗凋亡机制的研究[J].中国现代医学杂志,2005,15(24):3740-3742. 被引量:2
  • 3关泉林,于晓辉,霍永忠,李波.肝癌组织巨噬细胞移动抑制因子的表达及对肿瘤细胞增殖和血管形成的影响[J].世界华人消化杂志,2007,15(1):39-45. 被引量:8
  • 4FUJIMOTO H,SANGAI T, ISHII G,et al. Stromal MCP-1 in mammary tumors induces tumor-associated macrophage infiltration and contributes to tumor progression Journal Article [ J ]. Int J Cancer, 2009,125 (6): 1 276-- 1 284.
  • 5BAILEY C ,NEGUS R,MORRIS A,et al. Chemokine exp- ression is associated with the accumulation of turnout associated macrophages (TAMs) and progression in human colorectal cancer Journal Article [ J ]. Clin Exp Metastasis, 2007,24(2):121--130.
  • 6KURODA T,KITADAI Y,TANAKA S, et al. Monocyte c- hemoattractant protein-1 transfection induces angiogenesis and tumorigenesis of gastric carcinoma in nude mice via macrophage recruitment Journal Article [J]. Clin Cancer Res, 2005,11 (21 ):7 629--7 636.
  • 7KOIDE N, NISHIO A, SATO T, et al. Significance of mac- rophage chemoattractant protein-1 expression and macrophage infiltration in squamous cell carcinoma of the esophagus Journal Article [J]. Am J Gastroenterol, 2004,99( 9 ): l 667-- 1 674.
  • 8KLEINE-LOWINSKI K,GILLITZER R,KUHNE-HEID R, et al. Monocyte-chemo-attractant-protein-1 (MCP-I) -gene expression in cervical intra-epithelial neoplasias and cervical carcinomas Journal Article [J]. Int J Cancer, 1999,82( 1 ):6-- 11.
  • 9NEUMARK E, ANAVI R, WITZ I P, et al.MCP-1 express- ion as a potential contributor to the high malignancy phenotype of murine mammary adenocarcinoma cells Journal Article[J]. Immunol Lett, 1999,68( 1 ):141 -- 146.
  • 10YOSHIDOME H, KOHNO H,SHIDA T,et al. Significance of monocyte chemoattractant protein-1 in angiogenesis and survival in colorectal liver metastases Journal Article [J]. Int J Oncol, 2009,34 (4) :923 -- 930.

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