疏水性胆汁酸诱导肝细胞损伤机制研究进展

Mechanisms of hydrophobic bile acid mediating hepatocyte injury

疏水性胆汁酸又称毒性胆汁酸,在胆汁淤积性肝病中,毒性胆汁酸在肝内滞留,可通过氧化应激反应诱导细胞线粒体功能紊乱和内质网应激、刺激促炎性介质产生以及激活死亡受体等方式导致肝细胞的损伤、坏死和凋亡。毒性胆汁酸在胆汁淤积所致肝损害过程中起重要作用,文中就疏水性胆汁酸诱导肝细胞损伤的几种常见机制作一综述。

Hydrophobic bile acid （HBA）, also called toxic bile acid, accumulates in the liver of the patient with cholestatic diseases. Through oxidative stress response, it may induce mitochondrial function disorder and endoplasmic reticulum stress, stimulate the production of inflammatory mediators and activate the death acceptor, resulting in the damage, necrosis and apoptosis of liver ceils. HBA plays an important role in cholestasis-induced hepatocyte injury. This article outlines some common mechanisms of HBA mediating hepatocyte injury.