鲑鱼降钙素联合葡萄糖酸钙对老年性骨质疏松骨代谢指标的影响

Effects of salmon calcitonin combined with calcium gluconate on bone metabolism in senile osteoporosis patients

目的探讨鲑鱼降钙素联合葡萄糖酸钙对老年性骨质疏松骨代谢指标的影响。方法 105例老年性骨质疏松患者随机分为两组:鲑鱼降钙素组56例,给予鲑鱼降钙素和葡萄糖酸钙治疗;对照组49例,单纯给予葡萄糖酸钙治疗。治疗24周后比较治疗前后血清钙、磷、碱性磷酸酶(ALP)、骨碱性磷酸酶(B-ALP)、骨钙素(BGP)及尿中钙/肌酐比值和骨密度的变化。结果治疗24周后,鲑鱼降钙素组血清骨钙素和骨密度均明显升高(P<0.05),血B-ALP和尿钙/肌酐比值均显著下降(P<0.01),对照组均无显著改变。两组血ALP、钙、磷浓度无显著改变(P>0.05)。结论鲑鱼降钙素联合葡萄糖酸钙疗法治疗老年性骨质疏松、改善骨代谢优于单纯葡萄糖酸钙疗法;联合治疗能改善老年性骨质疏松骨代谢异常,影响骨矿化,促进骨形成。

Objective To investigate the effects of salmon calcitonin combined with calcium gluconate on bone metabolism in senile osteoporosis patients. Methods One hundred and five elderly osteoporosis patients were randomly divided into 2 groups. Patients （56 cases） in the salmon calcitonin group were treated with salmon calcitonin and calcium gluconate. Patients （49 cases） in the control group were treated with calcium gluconate. The levels of serum calcium, phosphorus, ALP, B-ALP, BGP, urinary calcium/ creatinine ratio, and bone mineral density （BMD） were carefully detected and compared before and after the 24-week treatment. Results The levels of serum BGP and BMD increased significantly （P 〈 0.05） and serum ALP and calcium/creatinine ratio in urine decreased （ P 〈 0. 01 ） in salmon calcitonin group. However, no significant change was found in the control group. No significant changes of serum calcium, phosphorus and ALP were found in both groups. Conclusion The efficacy of salmon calcitonin combined with calcium gluconate is superior to calcium gluconate for the treatment of elderly osteoporosis. The combined treatment can improve bone metabolism, influence bone mineralization, and accelerate bone formation.