围术期布托啡诺预先镇痛预防骨关节病患者术后长期慢性疼痛的效果

Effects of perioperative preemptive analgesia with butorphnol on preventing chronic pain after the bone- joint operation in a long term period

目的观察围术期布托啡诺预先镇痛对预防骨关节病患者术后长期慢性疼痛的效果。方法择期行骨关节手术的患者40例，随机分为A组（预先镇痛组）、B组（对照组），每组20例。A组患者从术前30min开始，静脉给予布托啡诺30μg／kg，每间隔4h重复1次，直到术后72h；B组患者围术期不做特殊的处理，只在术后患者主诉疼痛难忍时给予布托啡诺30μg／kg。出院后1年内对两组患者每月随访1次。结果A组患者术后发生骨关节疼痛的例数、VAs评分、需要口服镇痛药缓解疼痛的例数及其剂量均少于B组（P〈o．05）。结论围术期布托啡诺预先镇痛可降低骨关节病术后长期慢性疼痛的发生率和疼痛程度。

Objective To observe the effects of perioperative preemptive analgesia with butor- phnol on preventing chronic pain after the bone-joint operation. Methods Forty patients undergoing selective bone-joint operation were randomly divided into two groups, group A （butorphnol group） and group B （control group）, 20 patients in each group. The patients were given butorphanol 30 μg/kg before the operation and repeated every 4 hours, lasting to 72 hours after the operation in group A. The patients were received nothing except butorphanol 30 μg/kg when the patients could not bear the pain in group B. The patients were followed-up every month until one year. Results The number of patients appearing chronic pain,VAS, necessary to take analgesics and its dose in group A were all less than those in group B （P〈0.05）. Conclusion The perioperative preemptive analgesia with bu- torphanol can effectively prevent chronic pain after the bone-joint operation in a long term period.