林下山参水提液缓解运动性疲劳的研究

Anti-fatigue effect of water extract of Mountain Cultivated Ginseng

目的:研究林下山参缓解运动性疲劳的作用。方法:在小鼠抗疲劳实验中,将50只小鼠随机分为空白组(蒸馏水)、园参组CG(0.33g.kg-1)和3个林下山参组MCGL(0.17g.kg-1)、MCGM(0.33g.kg-1)、MCGH(0.50g.kg-1),分别灌胃蒸馏水和相应药物,每天1次(0.1mL.g-1.BW-1),30d。末次灌胃后,记录负重小鼠力竭游泳时间,测定小鼠无负重游泳后,肝糖原、血乳酸(LAC)、血尿素氮(BUN)、丙二醛(MDA)的含量和乳酸脱氢酶(LDH)活性。结果:与空白组和圆参组比较,林下参中高剂量组能显著延长负重小鼠力竭游泳时间,提高小鼠运动后体内肝糖原的含量和乳酸脱氢酶的活性,降低血尿素氮(BUN)和血乳酸(LAC)的含量。结论:林下山参具有良好的抗运动性疲劳作用。

Objective：To research on the anti-fatigue effect of Mountain Cultivated Ginseng.Methods：50 ICR mice were divided into a control group,a Cultivated Ginseng,group（CG,0.33g·kg^-1）,and three Mountain Cultivated Ginseng group MCGL（0.17g·kg^-1）,MCGM（0.33g·kg^-1）,MCGH（0.50g·kg^-1）,which were given distilled water and the corresponding drugs via gastrogavage.Mice were administrated one time per day（0.1mL·g-1 of body weight）,and continuous administration.Thirty days later,the exhaustive swimming time were recorded.In an exhaustive swimming task,the five indexes of lactic acid levels（LAC）,blood urea nitrogen（BUN） levels,liver glycogen stores,lactic dehydrogenase activity and malondialdehyde（MDA） levels of the mice were tested and analyzed.Results：Compared with the control group and CG,MCGM and MCGH could prolonged exhaustive swimming time,reduced BUN levels,decreased accumulation of lactic acid in the blood,and increased liver glycogen levels and Lactic Dedydrogenase activity.Conclusion：Mountain Cultivated Ginseng had obvious effect of anti-fatigue.