速溶芦笋粉改善睡眠功能的研究

Study on the sleep improvement effect of the instant asparagus powder

目的:研究速溶芦笋粉对小鼠改善睡眠的影响。方法:18～22g健康雄性昆明种小鼠,按体重随机分组,每天经口灌胃不同剂量速溶芦笋粉和阳性对照物(酸枣仁皂苷),观察小鼠直接睡眠作用,连续给予受试物30d后,进行戊巴比妥钠阈下剂量催眠实验、巴比妥钠睡眠潜伏期实验、延长戊巴比妥钠睡眠时间实验。结果:速溶芦笋粉的低中、高剂量组的睡眠发生率分别为25.00%、33.33%和41.67%,均比空白对照组显著增加,表明速溶芦笋粉具有协同戊巴比妥钠阈下剂量催眠作用;速溶芦笋粉的低、中、高剂量组的睡眠潜伏期分别为23.09、20.29、20.22min,与空白对照组的睡眠潜伏期32.36min相比显著缩短;速溶芦笋粉的低、中、高剂量组的睡眠时间分别为35.89、40.62、45.78min,与空白对照组的睡眠时间29.24min相比,显著延长戊巴比妥钠睡眠时间,但无直接改善睡眠作用。结论:速溶芦笋粉具有改善睡眠功能的作用。

Objective：To study the sleep improvement effect of instant asparagus powder on mice.Methods：Healthy KM male mice with the body weight of 18~22g were divided into groups randomly,then mice were gavaged with the different dosage of instant asparagus powder and jujubosided respectively everyday,and the direct sleep effect of the test material on mice were observed.30d later,the hypnosis test under subthreshold dose of Sodium Pentobarbital,the incubation period test with Barbital Sodium and the sleep extending test with Sodium Pentobarbital were conducted.Results：The sleep rate of low,medium and high dose group of instant asparagus powder were 25.00%,33.33% and 41.67% respectively,significantly raised the sleep rate comparing with the control group,it showed that the instant asparagus powder had hypnotic effect under the threshold hypnotic dosage of pentobarbital sodium.The sleeping incubation period of low,medium and high dose group of instant asparagus powder were 23.09,20.29,20.22min respectively,compared with the control group time 32.36min,instant asparagus powder significantly shorten the sleep incubation period of mice.The sleep time of low,medium and high dose group of instant asparagus powder were 35.89,40.62,45.78min respectively,the result showed that instant asparagus powder could significantly prolong sleep time that induced by pentobarbital sodium.Conclusion：Instant asparagus powder could improve the sleeping quality of mice.