维吾尔族和汉族女性雌激素受体-α基因多态性频率分布比较

Comparison of the distribution frequency of estrogen receptor-α gene polymorphism between Uygur and Han women

目的探讨新疆地区维吾尔族(维族)和汉族女性雌激素受体-α(estrogen receptor-α,ER-α)基因多态性的分布情况和种族间差异。方法新疆地区无亲缘关系、年龄20～40岁160名汉族健康女性和135名维族健康女性,应用聚合酶连反应限制性片段长度多态性技术检测ER-α基因XbaⅠ及PvuⅡ多态性。结果维、汉族女性ER-αXbaⅠ及PvuⅡ位点基因型与等位基因频率分布均符合Hardy-Weinberg平衡定律;维、汉族女性ER-αXbaⅠ及PvuⅡ位点基因型与等位基因频率分布差异均有统计学意义(P<0.05)。结论新疆地区维、汉族女性ER-α基因多态具有差异性。

Objective To investigate the distribution and the difference in frequency of estrogen receptor-α gene polymorphism between Uygur and Han women in Xinjing.Methods The polymorphism of estrogen receptor-α XbaI and PvuⅡ genotypes were determined with polymerase chain reaction-restricted fragment length polymorphisms in 135 Uygur and 160 Han unrelated healthy women aged from 20 to 40 years in Xinjiang.Results ER-α XbaI and PvuⅡ gene polymorphism accorded with Hardy-Weinberg equilibrium in Uygur and Han women.There was a significant difference in PvuⅡ and XbaI polymorphisms between Uygur and Han women（P0.05）.Conclusion There is a significant difference in estrogen receptor-α polymorphism between Uygur and Han women in Xinjiang.