2011年深圳市健康人群登革热抗体水平及影响因素分析

Analysis on antibody level for dengue virus and its influence factor in health population in Shenzhen,2011

目的了解深圳市健康人群登革病毒的感染情况,探讨影响人群登革热抗体产生的因素。方法 2011年11月,随机抽取深圳市16～60岁健康人群907名,进行问卷调查并采集血清标本,用酶联免疫法(ELISA)检测登革热IgG抗体。结果深圳市16～60岁人群登革热IgG抗体阳性率为4.30%,其中以36～岁年龄组抗体阳性率最高。经非条件Logistic回归单因素和多因素分析,深圳市健康人群存在登革病毒的隐性感染,其中年龄较大、文化程度低、缺乏对登革热预防知识的了解、在深圳期间有在外露宿、现居住处周围蚊虫多和现居住处无防蚊设施等因素是登革热IgG抗体阳性率上升的影响因素。结论深圳市健康人群登革热隐性感染较常见,建议积极开展预防登革热的宣传教育,搞好环境卫生和做好个人蚊虫防护工作。

In order to explore the epidemic investigation and countermeasure of dengue virus（DV） among healthy people in Shenzhen and analyze its risk factors,907 healthy people aged from 16 to 60 were interviewed face-to-face with questionnaires and their sera were collected.Anti-DV IgG was detected with Enzyme-linked immunosorbent assay（ELISA）.It was found that the antibody positive rate was 4.30%,with highest ratio in the age of 36.Six factors were statistically significant both in univariate analysis and multivariate analysis of logistic regression.Senior citizen,low education level,lack of knowledge about dengue prevention,sleep in the open,dwelling with high density of mosquitoes and lack of mosquito control facilities might be the risk factors for the increasing positive rate of Anti-DV IgG.Results indicated that dengue virus infection is widely found in the healthy residents of Shenzhen.It is necessary to carry out health education of dengue control and emphasis on environmental sanitation and good personal mosquito protection work.