Pd-La/C催化加氢酰化一步合成扑热息痛

Paracetamol synthesis by one-step Pd-La/C catalytic hydrogenation and acylation

以对硝基酚 (PNP)为原料 ,Pd -La/C催化加氢一步合成对乙酰氨基酚。最佳工艺条件为在应温度 1 4 0℃ ,反应压力0 .7MPa,反应时间 2h ,对乙酰氨基酚的收率达 97%。

p Acetaminophenol is synthesized by one step Pd La/C catalytic hydrogenation using p nitrophenol as raw material. The optimal reaction conditions are as follows: reaction temperature 140℃, reaction pressure 0.7MPa and reaction time 2 hours. The p acetaminophenol yield is up to 97%.