摘要
背景与目的:胶质母细胞瘤是一种以微血管增生为特征的高度血管化的异生组织,但现有的抗血管生成药物对胶质瘤的治疗效果却不尽如人意。本文通过分析胶质母细胞瘤的微循环模式,为更好地理解胶质母细胞瘤的微循环构筑和靶向肿瘤养分供给系统的治疗提供新的视角。方法:采用CD34-PAS双重染色技术分析胶质母细胞瘤的微循环构筑。结果:胶质母细胞瘤的微血管密度大于正常脑组织,两者差异有统计学意义(P<0.001)。胶质母细胞瘤中存在血管内皮依赖性血管、肿瘤细胞依赖性血管、细胞外基质依赖性血管和马赛克血管4种微循环模式。结论:胶质母细胞瘤的微循环模式具有异质性。
BACKGROUND ＆ OBJECTIVE： Glioblastoma is one of the most angiogenic human tumors and characterized by microvascular proliferations. A better understanding of glioblastoma vaseulature is needed to optimize anti-angiogenic therapy that has shown a promising but ineomplet efficacy. METHODS： The present study examined 48 glioblastomas by CD34 endothelial marker periodic acid-Schiff （PAS） dual staining and found there were four types of microcirculation pattern in human glioblastomas： endothelium dependent vessels, tumor cell dependent vessels, extracellular matrix （ECM） dependent vessels, and mosaic vessels. RESULTS： We confirmed subsequently that these four types of blood supply sources for tumors also exist in xenografi model glioblastomas. CONCLUSION： Here, we described and sorted the microeirculation pattern in human glioblastomas systematically according to histologic evidences and open a new perspective for the anti-vascular treatment strategy.
出处
《中国神经肿瘤杂志》
2012年第2期76-83,共8页
Chinese Journal of Neuro-Oncology
基金
国家自然科学基金资助项目(NO.30571914
NO.30973478)
