摘要
背景与目的:室管膜瘤与少突胶质瘤混合十分罕见,本文报道我们收治的一例儿童间变性混合型室管膜瘤-少突胶质细胞瘤。方法:回顾性分析一例中枢神经系统间变性混合型室管膜瘤-少突胶质细胞瘤患者的临床资料,综合相关文献报道分析其诊断、治疗和预后。结果:该例患者首次发病年龄为10岁,首发部位为右额叶,在5年内原位复发一次,颅内远隔部位复发3次,先后接受5次手术,3程放疗和多程不同方案的化疗。病理诊断为间变性混合型室管膜瘤-少突胶质细胞瘤。与一般胶质瘤反复在原手术区域局部复发不同,本例患者多次出现颅内新的远隔部位转移病灶,经过反复手术+局部放疗及化疗等综合治疗,病情得到有效控制。结论:病理为间变性混合型室管膜瘤-少突胶质细胞瘤的病例十分罕见,而其生物学特性和治疗预后明显区别于单一成分的间变性室管膜瘤或间变性少突胶质细胞瘤,临床上应予区别对待。
BACKGROUND ＆ OBJECTIVE： Ependymoma mixed with oligodendroglioma is rare. In this article, we report a case of anaplasia ependymoma-oligodendroglioma. METHODS： Clinical data of one patient with mixed anaplasia ependymoma-oligodendroglioma was reviewed. The diagnosis, treatment and prognosis were analyzedin combination with literature. RESULTS： A 10- year-old child first presented with right frontal lobe tumor, experienced 1 local recurrence and 3 distant recurrence in 5 years. The final diagnosis of the tumors was mixed anaplastic ependymoma-oligodendroglioma. The child received 5 surgeries, 3 irradiation and numerous chemotherapies. The patient is currently free of disease. The constantly new metastatic lesions grew in different brain lobes, which is different as compared to the persistently local recurrence happening in other common glioma patients. The disease has been controlled by combined treatment including surgery, radiotherapy and chemotherapy.CONCLUSION： Mixed anaplasia ependymoma-oligodendroglioma is an extremely rare type of glioma. The biological behaviors, pathological diagnosis of such glioma and the prognosis of the patient are obviously distinctive.
出处
《中国神经肿瘤杂志》
2012年第2期107-112,共6页
Chinese Journal of Neuro-Oncology
