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右美托咪定对脓毒症大鼠炎症反应和淋巴细胞凋亡的影响 被引量:16

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摘要 脓毒症是重症监护病房(ICU)患者常见死亡原因之一,目前认为,促炎/抗炎反应失衡及免疫细胞凋亡是脓毒症的重要发病机制。自主神经系统通过释放神经递质去甲肾上腺素(NE),作用于免疫细胞上的肾上腺素能受体(AR),调节脓毒症机体免疫功能。
出处 《中国危重病急救医学》 CAS CSCD 北大核心 2012年第9期558-561,共4页 Chinese Critical Care Medicine
基金 国家临床重点专科项目资助(2011-872) 中华医学会课题(10YXH-01)
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  • 1Lang JD, Matute-Bello G. Lymphocytes, apoptosis and sepsis:making the jump from mice to humans. Crit Care, 2009,13: 109.
  • 2Elenkov i J, Wilder RL, Chrousos GP, et al. The sympathetic nerve--an integrative interface between two supersystems:the brain and the immune system. Pharmzcol Rev, 2000,52 : 595-638.
  • 3Kumar V, Sharma A. ls neuroimmuno- modulalion a future therapeutic approach for sepsis?, Int hnmunopharmaeol,2010, 10:9-17.
  • 4Lai YC, Tsai PS, Huang CJ. Effects of dexmedetomidine on regulating endotoxin-induced up-regulation of inflammatory molecules in murine macrophages. J Surg Res,2009,154:212- 219.
  • 5Taniguchi T, Kurita A, Kobayashi K, et al. Dose- and time-related effects of dexmedetomidine on mortality and inflammatory responses to endotoxin- induced shock in rats. J Anesth, 2008,22 : 221-228.
  • 6白静慧,丁环,蒋雷,马建齐,俞伟平,臧彬.槲皮素对脓毒症急性肺损伤大鼠肿瘤坏死因子-α/白细胞介素-1β的影响[J].中国中西医结合急救杂志,2011,18(5):293-295. 被引量:16
  • 7Bao JY, Huang Y, Wang F, et al. Expression of alpha-AR subtypes in T lymphocytes and role of the alpha-ARs in mediating modulation of T cell function. Neuroimmunomodulation, 2007,14 : 344- 353.
  • 8Mosmann TR, Sad S. The expanding universe of T-cell subsets:Th1,Th2 and ruore. Immunnl Today, 1996,17 : 138-146.
  • 9Kohm AP, Sanders VM. Nore- pinephrine and beta 2 - adrcnergic receptor stimulation regulalc CD4+T and B lymphocyte function in vitro and in vivo. Pharmacol Rev, 2001,53 : 487-525.
  • 10张畔,郭聪芳,骆宁,王兵,徐新女.脓毒症大鼠脾脏淋巴细胞凋亡的实验研究[J].中国危重病急救医学,2009,21(12):726-728. 被引量:6

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  • 1纪木火,吴晶,李仁奇,田蜜,朱四海,李伟彦,杨建军.右旋美托咪啶对脓毒血症大鼠急性肺损伤的影响[J].中华临床医师杂志(电子版),2011,5(21):6434-6436. 被引量:10
  • 2张磊,石斌,李斌,侯启亮,张志刚.盐酸右美托咪定对机械通气患者镇静的效果与安全性[J].兰州大学学报(医学版),2013,39(4):58-60. 被引量:12
  • 3吴新民,许幸,王俊科,王鲲鹏,薛张纲,缪长虹,邓小明,艾登斌,于浩.静脉注射右美托咪啶辅助全身麻醉的有效性和安全性[J].中华麻醉学杂志,2007,27(9):773-776. 被引量:242
  • 4Grewal A. Dexmedetomidine : new avenues. J Anaesthesiol Clin Pharmacol,2011,27 (3) :297-302.
  • 5Bennett GJ, Xie YK. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain, 1988,33 (1) :87-107.
  • 6Holmes BB, Fujimoto JM. Inhibiting a spinal dynorphin A component enhances intratheeal morphine antinoeiception in mice. Anesth Analg, 1993,77 (6) : 1116-1173.
  • 7Chaplan SR, Bach FW, Pogrel JW, et al. Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods, 1994,53 ( 1 ) : 55-63.
  • 8Hargreaves K, Dubner R, Brown F, et al. A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain, 1988,32 ( 1 ) : 77-88.
  • 9Hwaug JH, Yaksh TL. The effect of spinal GABA receptor agonists on tactile allodynia in a surgically-induced neuropathic pain model in the rat. Pain, 1997,70 ( 1 ) : 15-22.
  • 10Moalem G, Tracey DJ. Immune and inflammatory mechanisms in neuropathic pain. Brain Res Rev, 2006,51 (2) : 240-264.

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