T淋巴细胞毒相关抗原-4基因49位点多态性与儿童1型糖尿病相关性的Meta分析

Association of cytotoxic T lymphocyte-associated antigen-4+49A/G polymorphism with childhood type 1 diabetes mellitus:a meta-analysis

目的评价T淋巴细胞毒相关抗原-4(CTLA-4)基因49位点多态性与儿童1型糖尿病(T1DM)的相关性。方法检索PubMed、EBSCO、中国学术期刊全文数据库(CNKI)、中国生物医学文献数据库(CBM)、万方数据库,收集CTLA-4基因49位点多态性与儿童T1DM相关性的文献。用Meta分析的方法检测CTLA-4基因49位点的基因型和等位基因在儿童T1DM组与对照组中是否有差异。结果共纳入10篇文献,共有T1DM 1084例,对照组1338例。根据各项研究的异质性检验结果,均利用固定效应模型对CTLA-4基因49位点的AG、GG、GG+AG基因型和G等位基因与T1DM相关性进行Meta分析,各项研究的合并OR值(95%CI)分别为1.13(0.97～1.33)、1.42(1.16～1.75)、1.20(1.03～1.40)、1.21(1.09～1.33),提示T1DM组CTLA-4基因49位点G等位基因和GG、GG+AG基因型表达与对照组比较均有显著差异。结论 CTLA-4基因49位点G等位基因和GG、GG+AG基因型均与儿童T1DM的发生相关。

Objective To evaluate the association of cytotoxic T lymphocyte-associated antigen-4（CTLA-4）＋49A/G polymorphism with type 1 diabetes mellitus（T1DM） in children.Methods Papers about the association of CTLA-4＋49A/G polymorphism with T1DM in children were collected by searching PubMed,EBSCO,CBM,CNKI,and Wanfang Data.A meta-analysis was performed to examine differences in the genotypes（AG,GG,and GG＋AG） and G allele at position 49 of the CTLA-4 gene between a childhood T1DM group and a control group.Results A total of 10 papers involving 1084 T1DM children and 1338 healthy children were included.The Meta-analysis was performed to evaluate the association of the genotypes（AG,GG,and GG＋AG） and the G allele at position 49 of the CTLA-4 gene with T1DM using a fixed effect model according to the heterogeneity test results of all studies.The pooled OR values（95% CI） were 1.13（0.97-1.33）,1.42（1.16-1.75）,1.20（1.03-1.40）,and 1.21（1.09-1.33）,suggesting a significant difference in genotypes（AG,GG,and GG＋AG） and the G allele at position 49 of the CTLA-4 gene between the two groups.Conclusions CTLA-4 ＋49A/G polymorphism is associated with T1DM in children.