摘要
目的评价T淋巴细胞毒相关抗原-4(CTLA-4)基因49位点多态性与儿童1型糖尿病(T1DM)的相关性。方法检索PubMed、EBSCO、中国学术期刊全文数据库(CNKI)、中国生物医学文献数据库(CBM)、万方数据库,收集CTLA-4基因49位点多态性与儿童T1DM相关性的文献。用Meta分析的方法检测CTLA-4基因49位点的基因型和等位基因在儿童T1DM组与对照组中是否有差异。结果共纳入10篇文献,共有T1DM 1084例,对照组1338例。根据各项研究的异质性检验结果,均利用固定效应模型对CTLA-4基因49位点的AG、GG、GG+AG基因型和G等位基因与T1DM相关性进行Meta分析,各项研究的合并OR值(95%CI)分别为1.13(0.97~1.33)、1.42(1.16~1.75)、1.20(1.03~1.40)、1.21(1.09~1.33),提示T1DM组CTLA-4基因49位点G等位基因和GG、GG+AG基因型表达与对照组比较均有显著差异。结论 CTLA-4基因49位点G等位基因和GG、GG+AG基因型均与儿童T1DM的发生相关。
Objective To evaluate the association of cytotoxic T lymphocyte-associated antigen-4(CTLA-4)+49A/G polymorphism with type 1 diabetes mellitus(T1DM) in children.Methods Papers about the association of CTLA-4+49A/G polymorphism with T1DM in children were collected by searching PubMed,EBSCO,CBM,CNKI,and Wanfang Data.A meta-analysis was performed to examine differences in the genotypes(AG,GG,and GG+AG) and G allele at position 49 of the CTLA-4 gene between a childhood T1DM group and a control group.Results A total of 10 papers involving 1084 T1DM children and 1338 healthy children were included.The Meta-analysis was performed to evaluate the association of the genotypes(AG,GG,and GG+AG) and the G allele at position 49 of the CTLA-4 gene with T1DM using a fixed effect model according to the heterogeneity test results of all studies.The pooled OR values(95% CI) were 1.13(0.97-1.33),1.42(1.16-1.75),1.20(1.03-1.40),and 1.21(1.09-1.33),suggesting a significant difference in genotypes(AG,GG,and GG+AG) and the G allele at position 49 of the CTLA-4 gene between the two groups.Conclusions CTLA-4 +49A/G polymorphism is associated with T1DM in children.
出处
《中国当代儿科杂志》
CAS
CSCD
北大核心
2012年第9期683-688,共6页
Chinese Journal of Contemporary Pediatrics