2006-2010年我院临床分离大肠埃希菌和肺炎克雷伯菌的耐药性监测

Drug resistance of Escherichia coli and Klebsiella pneumoniae isolated in our hospital from 2006 to 2010

目的分析2006-2010年我院临床分离的大肠埃希菌1722株和肺炎克雷伯菌872株对常用抗菌药物耐药性的变迁情况。方法采用VITEK-32全自动微生物鉴定及药敏分析系统对大肠埃希菌与肺炎克雷伯菌鉴定并行药敏试验,应用WHONET5.4软件对药敏结果进行统计。结果2006-2010年从临床送检的标本中共分离出大肠埃希菌1722株和肺炎克雷伯菌872株,两种细菌对常用的多种抗菌药物,特别是3代头孢菌素产生相当程度的耐药性,仅对美洛培南敏感性较好。结论临床应根据药敏试验结果,合理选用抗菌药物,防止医院感染。

Objective To monitor the drug resistance of 1 722 stains of Escherichia coli （E. coil） and 872 stains ofKlebsiella pneumoniae isolated in our hospital from 2006 to 2010. Methods Strains orE. coli and Klebsiella pneumoniae were identified by VITEK-32 Automatic Microbial Identification and analyzed by drug-susceptibility test- ing. Then the results were analyzed using WHONET5.4 software. Results From 2006 to 2010, the 1 722 stains of E. coli and 872 stains of Klebsiella pneumoniae isolated were highly resistant to most commonly used antimicrobial drugs, especially the third generation of cephalosporin drugs. They were found to be highly susceptible to meropenem. Conclusion The drug resistance of E. coli and Klebsiella pncumoniae from hospital infection is very serious. We should strengthen the monitoring of the antibiotic resistance of pathogens. The antimicrobial agents should be used rea- sonably based on the results of susceptibility tests.