骨折合并Ⅱ型糖尿病患者骨转换生化指标及骨折愈合的变化

The change of serum alkaline phosphatase and fracture healing about the fracture with type 2 diabetes

[目的]观察Ⅱ型糖尿病骨折患者骨转换生化指标-碱性磷酸酶及骨折愈合的变化。[方法]将在我科住院行手术治疗的骨折患者分为非糖尿病骨折组72例及Ⅱ型糖尿病骨折组79例,观察术前、术后两组患者血浆碱性磷酸酶(AKP)及骨折愈合情况。[结果]非糖尿病骨折组与Ⅱ型糖尿病骨折组比较,血AKP检测指标及骨折愈合情况差异具有显著性意义(P<0.01,P<0.05)。Ⅱ型糖尿病可影响骨折后血AKP浓度的变化及骨折愈合速度。[结论]Ⅱ型糖尿病可影响骨质代谢,并易造成骨折延缓愈合。

[ Objective ] To observe the change of serum alkaline phosphatase and fracture-healing about the fracture with type 2 diabetes. [ Method ] The patients with fracture were divided into two groups ： fracture-patient with type 2 diabetes, and fracture-patient with normal blood glucose. The change of serum alkaline phosphatase（AKP） and fracture-healing were observed in different groups. [ Result] AKP in the group of the fracture-patient with type 2 diabetes changed significantly as compared with the group of the fracture-patient with normal blood glucose. Type 2 diabetes would slow down the speed of fracture-healing （ P 〈 0.01 ）. [ Conclusion] Type 2 diabetes could influence the metabolism-speed of fracture-healing. Key words-type 2 diabetes, alkaline phosphatase, healing of fracture