老年2型糖尿病患者糖尿病视网膜病变危险因素分析

Analysis on the relative risk factors of diabetes retinopathy in older patients with type 2 diabetes mellitus

目的探讨老年2型糖尿病患者发生糖尿病视网膜病变的危险因素。方法选择2006年5月～2011年5月在笔者所在医院门诊治疗的120例老年2型糖尿病患者,根据有无视网膜病变分为观察组(糖尿病视网膜病变组)和对照组(非糖尿病视网膜病变组),其中观察组52例,对照组68例,记录两组患者的年龄、性别、病程、BMI、SBP、DBP、FBG、PBG2h、HbA1C、CRP、HCY、UA和血脂等指标,并进行统计学处理。结果观察组与对照组在病程、SBP、HbA1C、CRP、HCY、UA以及LDL方面差异有统计学意义(P<0.05或0.01);Logistic回归分析显示病程、SBP、HbA1C、CRP、HCY水平是视网膜病变发生的独立危险因素。结论病程和SBP、GHbA1C、CRP、HCY水平是糖尿病视网膜病变发生的重要危险因素,应重视并针对其危险因素进行早期干预。

Objective To study the risk factors of diabetes retinopathy in older patients with type 2 diabetes mellitus. Methods 120 cases of older patients with type 2 diabetes were retrospectively analyzed,who were divided into two groups,52 patients with diabetes retinopathy（DR） as the observation group and 68 patients without DR as the control group. To compare the date of gender,age,the course of the disease,SBP,DBP,BMI,FBG, PBG2h,HbAlc,CRP,HCY,UA and lipids in the two groups,and statistical analysis was carried out. Results There were significantly different in the course of the disease,SBP,HbAlc,CRP,HCY and UA between two groups（P 〈 0.05 or 0.01）.Logistic analysis revealed that the 5 variances,such as the course of the disease,SBP,HbAlc,CRP and HCY were the independent risk factors of DR. Conclusion The course of the disease,SBP,HbAlc,CRP and HCY are the main factors of diabetes retinopathy,we should take early intervention according to risk factors for early intervention