妊娠合并肝病对围产结局的影响研究

Research on perinatal outcome of the pregnancy complicated with liver disease

目的分析妊娠合并肝病情况,探讨有效预防和控制措施。方法回顾分析158例妊娠合并肝病患者临床资料。结果妊娠合并肝炎96例(60.76%),合并肝内胆汁淤积28例(17.72%),肝炎+肝内胆汁淤积症20例(12.66%),合并急性脂肪肝9例(5.70%),药物性肝损害5例(3.16%);早孕合并肝病13例(8.23%),中孕17例(10.76%),晚孕128例(81.01%);发生妊高征19例,DIC11例,肝性脑病10例,肾衰10例,产后出血22例,死亡9例。结论妊娠合并肝病是危害母婴健康的严重疾病,应加强孕期保健与监测,积极治疗肝病,减少母婴死亡与产后出血发生率。

Objective To analyze the situation of pregnancy complicated with liver disease and explore the precautionary measure and control measures. Methods Retrospectively analyzed the clinical data of 158 patients with pregnancy complicated with liver disease. Results The pregnancy complicated hepatitis were 96 cases（60.76%）.The complicated intrahepatic cholestasis were 28 cases（17.72%）.Hepatitis and intrahepatic cholestasis were 20 cases（12.66%）.Complicated acute fatty liver were 9 cases（5.70%）.Drug induced liver injury 5 were cases（3.16%）.Early pregnancy complicated pregnancy complicated with liver disease were 13 cases （8.23%）.Metaphase pregnancy were 17 cases（10.76%）.Late pregnancy were 128 cases（81.01%）.Happen pregnancy induced hypertension syndrome were 19 cases.DIC wre 11 cases.Hepatic encephalopathy were 10 cases. Renal failure were 10 cases.Postpartum hemorrhage were 22 cases.9 cases were dead. Conclusion Pregnancy complicat was a seriously illness to harm maternal and infant health.The prenatal care and monitoring should be strengthened.Actively treating liver disease can reduce the incidence rate of maternal and infant death and postpartum hemorrhage.