期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

DNA甲基化与脂肪组织生长发育 被引量：8

DNA Methylation and Adipose Tissue Development
原文传递
导出
摘要 DNA甲基化作为一种重要的表观遗传学修饰方式,在维持正常细胞功能、遗传印记、胚胎发育以及人类肿瘤发生中起着重要作用。DNA甲基化最重要的作用是调控基因表达,它是细胞调控基因表达的重要表观遗传机制之一。近年来的研究发现,DNA甲基化在脂肪组织生长发育以及肥胖症发生过程中发挥着重要作用。DNA甲基化通过调控脂肪细胞分化转录因子、转录辅助因子以及其他脂肪代谢相关基因的表达,从而调控脂肪组织的生长发育。该文综述了脂肪组织生长发育过程中DNA甲基化的最新研究进展,探讨了脂肪组织DNA甲基化的研究趋势和未来发展方向。 DNA methylation is an important epigenetic modification and plays crucial roles in maintaining normal cellular functions,gene imprinting,embryonic development and human tumorigenesis.The key role of DNA methylation is the regulation of gene expression,and DNA methylation is one of several epigenetic mechanisms that cells use to regulate gene expression.Accumulating evidence has showed that DNA methylation plays an important role in adipose tissue development and obesity.DNA methylation regulates the expression of transcription factors,transcriptional cofactors,and other genes involved in adipose development and adipocyte differentiation.This article reviews recent advances in research on DNA methylation of adipose tissue development,and discusses the ongoing trends and future research directions of DNA methylation in adipose tissue.
作者 高媛 孙婴宁 李辉 王宁
机构地区 东北农业大学动物科学技术学院农业部鸡遗传育种重点实验室
出处 《中国细胞生物学学报》 CAS CSCD 北大核心 2012年第9期916-923,共8页 Chinese Journal of Cell Biology
基金 国家重点基础研究发展计划(973计划)项目(No.2009CB941604) 黑龙江省高等学校科技创新团队建设项目 现代农业产业技术体系建设专项资金(No.CARS-42)资助项目~~
关键词 DNA甲基化 基因表达 脂肪组织 生长发育 DNA methylation gene expression adipose tissue growth and development
分类号 R346 [医药卫生—基础医学]
  • 相关文献

参考文献3

二级参考文献81

  • 1Kondo T. Epigenetic alchemy for cell fate conversion. Curr Opin Genet Dev 2006; 16:502-507.
  • 2McNairn A J, Gilbert DM. Epigenomic replication: linking epigenetics to DNA replication. Bioessays 2003; 25:647-656.
  • 3Qiu z, Wei Y, Chen N, Jiang M, Wu J, Liao K. DNA synthesis and mitotic clonal expansion is not a required step for 3T3- L1 preadipocyte differentiation into adipocytes. J Biol Chem 2001; 276:11988-11995.
  • 4Patel YM, Lane MD. Mitotic clonal expansion during preadipocyte differentiation: calpain-mediated turnover of p27. J Biol Chem 2000; 275:17653-17660.
  • 5Tang QQ, Otto TC, Lane MD. Mitotic clonal expansion: a synchronous process required for adipogenesis. Proc Natl Acad Sci USA 2003; 100:44-49.
  • 6Huo H, Guo X, Hong S, Jiang M, Liu X, Liao K. Lipid rafts/caveolae are essential for insulin-like growth factor-1 receptor signaling during 3T3-L1 preadipocyte differentiation induction. JBiol Chem 2003; 278:11561-11569.
  • 7Lin FT, Lane MD. CAAT/enhancer binding protein alpha is sufficient to initiate the 3T3-L1 adipocyte differentiation program. Proc Natl Acad Sci USA 1994; 91:8757-8761.
  • 8Tada Y, Brena RM, Hackanson B, Morrison C, Otterson GA, Plass C. Epigenetic modulation of tumor suppressor CCAAT/enhancer binding protein alpha activity in lung cancer. J Natl Cancer Inst 2006; 98:396-406.
  • 9Ng RK, Gurdon JB. Epigenetic memory of an active gene state depends on histone H3.3 incorporation into chromatin in the absence of transcription. Nat Cell Biol2008; 10:102-109.
  • 10Beaujean N, Taylor J, Gardner J, Wilmut I, Meehan R, Yong L. Effect of limited DNA methylation reprogramming in the normal sheep embryo on somatic cell nuclear transfer. Biol Reprod2004; 71:1854193.

共引文献51

同被引文献56

  • 1于传军,周波,吴建海,黄瑞华,韦习会,刘红林,王林云.新淮猪瘦肉系杂交育肥及胴体性能测定[J].畜牧与兽医,2005,37(6):27-28. 被引量：4
  • 2刘勇,陈文斌,张曦,高士争.生长因子对猪脂肪细胞分化的调控[J].黑龙江畜牧兽医,2006(5):19-21. 被引量：1
  • 3颜斌,曹仁贤,文格波.DNA甲基化与基因转录抑制[J].国际病理科学与临床杂志,2006,26(6):524-526. 被引量：5
  • 4Gao S Z, Zhao S M. Physiology, affecting factors and strategies for control of pig meat intramuscular fat [ J ]. Recent Patents on Food, Nutrition and Agriculture ,2009,1 ( 1 ) :59-74.
  • 5Louet J F,Coste A,Amazit L,et al. Oncogenic steroid receptor coactivator-3 is a key regulator of the white adipogenic program[ J]. Proc Natl Acad Sci USA,2006,103(47) : 17868-17873.
  • 6Ma X, Xu L, Wang S, et al. Deletion of steroid receptor coactivator-3 gene ameliorates hepatic steatosis [ J ]. Journal of Hepatology, 2011,55 (2) : 445-452.
  • 7Coste A,Louet J F, Lagouge M, et al. The genetic ablation of SRC-3 protects against obesity and improves insulin sensitivity by reducing the acetylation of PGC-lct[ J]. Proc Natl Acad Sci USA,2008,105(44) :17187-17192.
  • 8Hartig S M, He B, Long W, et al. Homeostatic levels of SRC-2 and SRC-3 promote early human adipogenesis [ J ]. The Journal of Cell Biology, 2011,192( 1 ) :55-67.
  • 9Bird A P. CpG-rich islands and the function of DNA methylation [ J ]. Nature, 1985,321 (6067) :209-213.
  • 10Eckhardt F, Lewin J, Cortese R, et al. DNA methylation profiling of human chromosomes 6,20 and 22 [ J ]. Nature Genetics,2006,38 (12) : 1378- 1385.

引证文献8

二级引证文献18

中国细胞生物学学报
2012年 第9期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部